Theories Of Antibody Production Have Had A Long And Rich History

2034 Words Sep 26th, 2014 9 Pages
Essay: Clonal Selection Theory
Theories about antibody production have had a long and rich history (1). The solutions to the questions surrounding how the immune system can target and destroy a diverse range of foreign organisms to the body were postulated by Frank Macfarlane Burnet in the latter half of the 20th century (2). The research covered by his peers earlier in the century helped Burnet hone his theory on clonal selection. His theory, and the development of new applications of molecular biology, impacted to change both the methods and the concepts of modern immunology (2, 3, 4 & 5). Through the clonal selection theory, modern immunologists have acquired a more detailed understanding of the chemical and recognition mechanisms employed by the immune system to destroy foreign invaders. This is useful in a variety of areas in the medical field, particularly to do with the prevention, diagnosis and treatment of diseases such as autoimmune diseases, cancers and tumours (5 & 11). One way this is being accomplished is through the production of monoclonal antibodies, such as hybridomas (5). Clonal selection has also proved to be a fundamental in the advancement of immunological understanding and presents the foundation on which modern immunological theories are described.
In the first half of the twentieth century Paul Ehrlich, Karl Landsteiner, Fritz Breinl, Felix Haurowitz and Linus Pauling all suggested theories to explain how the immune system produced antibodies and why…
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