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Therapeutic Healing: A Case Study

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healing process, these phases are defined as the inflammatory phase, the proliferative phase (the development of granulation tissue), and the regeneration phase, including maturation, scar for- mation, and re-epithelialization.24
The inflammatory phase begins with damage of capillaries, triggering the formation of a blood clot consisting of fibrin and fibronectin. This provisional matrix fills in the lesion and allows a variety of recruited cells to migrate into the lesion. Platelets present in the blood clot release multiple chemokines, which partici- pate in the recruitment of inflammatory cells, neutrophils, and macrophages, but also in chemotaxis and recruitment of fibroblasts and endothelial cells.

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