Therapeutic Response Of A Drug Depends Upon The Dissolution Rate Of Water Insoluble Drugs Essay

Aspirin, Caffeine and Salicylamide were extracted from an over-the-counter pain reliever (BC Powder). These components were separated by manipulating their solubilities by adjusting the acidity and basicity of the solution. By doing this, the three components were forced into conjugate acid (or base) forms, causing selective solubility in either an aqueous or organic solvent. These layers were then separated by use of a separation funnel. Once separated, the components extracted were characterized by measuring the melting point and performing a TLC analysis. Also, the recovered aspirin from the first part of the experiment was recrystallized and compared to that of the

Phenacetin’s cold water solubility is 0.076 grams/100 mL of water, whereas its boiling water solubility is 1.22 grams/100 mL of water. In this experiment, water solubility will be an indicator for how much boiling water to use in recrystallization, which purifies the unknown precipitate produced in the second lab. If a substance has higher water solubility in boiling water, such as acetanilide compared

Hypothesis: It was hypothesised the colder the water is, the slower the tablet dissolves and the hotter the water gets, the faster the tablet dissolves. This is due to the particles heating up and getting excited thus separating the particles faster. It was suspected that the 20°C tablet in water would finish dissolving at 6 minutes, the 40° would dissolve at 4 minutes and the 50° would dissolve at 2 minutes. Also it was suspected that the 30°C tablet in water would dissolve after 4 minutes and the 60°C would finish dissolving after 1 minute.

The majority of medicines are formulated for oral administration. This means they are taken via the mouth, in the form of a tablet, capsule, liquid or suspension. These medicines come in a variety of

The antacid tablets were not crushed properly, resulting in big crumbs of the tablet which will affect the dissolving process of the lab.

Oral - medicines can be given orally in the form of capsules, tablets, liquids or powders.

In the experiment, we tested three different water temperatures, boiling water (212*F), room temperature water (68* F), and ice water (40* F), and tested the amount of time it took for the Alka-Seltzer tablet to dissolve. In the boiling water, the Alka-Seltzer tablet dissolved in twenty-four seconds, in the room temperature water, the tablet dissolved in fifty seconds, and in the ice water, the tablet dissolved in one hundred seconds.

Manufacturing theophylline formulations come with challenges for both the anhydrous and hydrate. For the anhydrous form, a study showed that the wet granulation of theophylline anhydrous in conjunction with microcrystalline cellulose, led to the formation of the monohydrate form of the drug. This is significant because the monohydrate has slower dissolution than the anhydrous form of theophylline. Thus the method of manufacture is highly important as the study showed directly compressed pellets had better dissolution profiles. Also it shows the importance of the choice of excipients as pellets manufactured via wet granulation in the absence of microcrystalline cellulose showed similar release to that of directly anhydrous theophylline.

Which brand of painkilling medicine dissolves the fastest and does flavor, coating, and color of the pill affect the dissolution time? If several different pain neutralizing pills are placed in stomach acid and timed in order to find out which pill dissolves first, then the most effective pill will be the first to dissolve. In order to test this, eight different types of pain neutralizing medicine were put into simulated stomach acid and timed. Normal strength, liquid gel capsules, and children's flavored pills were all tested. In order to accurately simulate stomach acid, vinegar, which has the same pH levels of stomach acid, was heated to thirty seven degrees Celsius and stirred constantly and evenly. The pills tested were Advil, Children's

Alka-Seltzer contains both baking soda (NaHCO3) and citric acid (H3C6H5O7). The reaction between the bicarbonate ion and citric acid produces water, carbon dioxide, and the citrate ion. Equation 1 shows the balanced equation for the reaction, which can be expressed by, C_6 H_8 O_7 (aq)+ 3NaHCO_3 (aq)→ 3H_2 O(l) + 3CO_2 (g) + Na_3 C_6 H_5 O_7 (aq) (1)

Patients walk into our clinics daily with a variety of complaints. Many things we can observe and assess drive our decisions for plans of care. However, there are some things about our patients we can’t see. Some things nobody would know under normal circumstances. How most medications are metabolized is predictable across the population, but some medications throw us a curve ball. Polypharmacy is a necessity in primary care. As primary care providers (PCPs) we see patients for both chronic and acute pathologies. Understanding metabolic pathways is expected of us as providers, but that doesn’t make us invulnerable to poor outcomes despite best efforts. In the following

In the experiment, I predict that the acetaminophen liquid soft gel capsules will take the longest to dissolve in the simulation gastric acid. The capsules will be the second most effective based on its reaction to the simulation gastric acid. Lastly the liquid form will completely dissolve, therefore being the least effective.

Slow release: Enteric coated tablets are non crush, they are known as sustained-release tablets, which can be composed of

Distribution around the body occurs when the drug reaches the circulation(Neil, 2015), The literature states the route of administration does not have a particular effect on the half life of the drug, however, certain delivery systems like oral sustained release or matrix patch will affect the half life of the drug (Smith, 2008). Half-life is the term used to represent the time taken for the concentration of the drug in the blood to fall down to half of its original value (Neil, 2015). The time to steady dose and interval depends upon the half-life of the drug (Smith, 2008) and the half-life of codeine is 3 hours (Drug bank, 2015). Moreover, in opioids the dose intervals longer than the half-life will cause resurgence of pain, too short intervals

In week one we performed a qualitative solubility test of our fats and oils, synthesized our soaps and detergents, and performed a solubility test and lathering test for the soaps and detergents. We wanted to test the solubility of our starting materials of the soap making process to understand the properties of the materials. In our initial solubility test of the starting materials, we found that most of the materials were insoluble. As you can see in Table 2.0, olive oil and vegetable oil were only soluble in toluene and the shortening and lard were only partially soluble in acetone. In order to understand the solubility of the soaps and detergents, after our synthesis and filtration, we performed a qualitative solubility test with each of