Thyroid Cancer : A Common Endocrine Malignant Tumor Essay

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Thyroid cancer is a common endocrine malignant tumor (1). Papillary thyroid carcinoma (PTC) is the most common of the well-differentiated carcinomas (85%) (2) and is characterized by distinctive nuclear features. Most thyroid tumors can be readily diagnosed using histopathologic criteria, which allow the pathologist to differentiate benign from malignant lesions and guarantee an accurate classification for the majority of the variants of carcinomas derived from follicular epithelial cells. However, in most cases, the pathologist is confronted with thyroid lesions in which the distinction between benign and malignant can be quite subtle. The decision favoring one or another has clinical consequences and implies different modalities of treatment. For this reason, the approach to these challenging tumors should include ancillary techniques, immunohistochemistry and molecular profiling, that can improve the standard morphologic assessment (3). The cell division cycle 20 homolog (CDC20) is a regulatory protein that is a target molecule in the cell-cycle checkpoint. CDC20 is a component of the mammalian cell cycle mecha¬nism that activates the anaphase-promoting complex (APC). Its expression is essential for cell division and its protein activity may be con¬trolled by a balance between ubiquitination and de-ubiquitination. APC activation is required for anaphase initiation and mitosis exit (4). Interestingly, some researchers have shown that CDC20 might also play a role in

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