Thyroid Cancer Essay

Hashimoto’s Thyroiditis, also called Hashimoto’s disease is an autoimmune disease in which the body’s immune system attacks the thyroid gland. It was named for the Japanese surgeon who discovered it in 1912 The thyroid is a small butterfly shaped gland in the front of the neck. The thyroid makes hormones called T3 and T4. These hormones regulate metabolism. The thyroid is controlled by hormones of the pituitary gland, which is also called the “master gland.” It is a pea-sized gland located in the base of the brain which, among others, makes thyroid stimulating hormone, or TSH. TSH stimulates the thyroid to make thyroid hormone. With Hashimoto’s disease, the thyroid cells are damaged resulting in the inability to make enough thyroid

There are over 14 million cancer victims currently living in the United States. There are over 1,500,000 new cases of cancer that occur every year. Cancer is the number two cause of death in the United States just behind heart disease. There are over 500,000 cancer related deaths in the nation each year. Lung and bronchus cancer are the leading killers with over 150,000 deaths a year. Prostate cancer is the most diagnosed cancer for males with over 220,000 cases a year. For females, breast cancer is the most diagnosed form of cancer with over 230,000 cases a year. These statistics were pulled from www.cancer.org. Current trends suggest that these numbers may continue along their present rate but over time improved treatments will shift the

The thyroid is a butterfly-shaped gland. You would find it located in the lower neck, right below the Adam’s apple. The location is the same in both men and women. What the thyroid does is create and store thyroid hormone. It then releases the hormone in appropriate amounts to keep the body’s metabolism functioning at a normal level. If there is too much thyroid hormone, this is known as hyperthyroidism. In hyperthyroidism, the body’s metabolism increases. This condition can cause high blood pressure, high heart rate, nervousness, palpitations, and severe weight loss. Too little thyroid hormone, on the other hand, can cause tiredness, depression, memory loss, dry skin, brittle hair, and weight gain—among many other symptoms.

ATC likely arises from the loss of differentiation of other thyroid carcinomas, including papillary and follicular thyroid carcinomas. Mutations of the proto-oncogenes,

Commonly, problems with the thyroid involve an abnormal production level of these hormones. It is called hyperthyroidism if there the thyroid hormones are overproduced, and this can cause things like Graves’ disease, Toxic adenomas, and subacute thyroiditis (7). Hypothyroidism is the underproduction of the hormones which can be caused by an inflamed thyroid, iodine deficiency, a non-functioning thyroid gland and more. Hypothyroidism is especially dangerous in infants and newborns as the lack of these thyroid hormones can lead to mental retardation and dwarfism (7). However, in humans hypothyroidism can be caused by things such as a pituitary disorder, a defective thyroid or a lack of the gland completely. (7)

The symptoms are initially asymptomatic they begin to appear such as swelling in the neck, swelling in the lymph nodes and pain, hoarseness and difficulty to breath. The causes are exposure to high levels of radiation, inherited genetic syndromes. There are four types of thyroid cancer: papillary, medullary thyroid cancer, anaplastic thyroid cancer, thyroid lymphoma. According to cancercenters Papillary carcinoma is the most common type of thyroid cancer, accounting for approximately 80% of cases. Papillary carcinomas are slow growing, differentiated cancers that develop from follicular cells and can develop in one or both lobes of the thyroid gland. This type of cancer may spread to nearby lymph nodes in the neck, but it is generally treatable with a good prognosis (outlook for survival). Follicular carcinoma is the second most common type of thyroid cancer, and accounts for approximately one out of 10 cases. It is found more frequently in countries with an inadequate dietary intake of iodine. Follicular carcinoma is also a differentiated form of thyroid cancer. In most cases, it is associated with a good prognosis, although it is somewhat more aggressive than papillary cancer. Follicular carcinomas do not usually spread to nearby lymph nodes, but they are more likely than papillary cancers to spread to other organs, like the lungs or the bones. Hurtle cell carcinoma, also known as oxyphil cell carcinoma, is a subtype of follicular carcinoma, and accounts for approximately 3 percent of all thyroid cancers. Medullary thyroid carcinoma develops from C cells in the thyroid gland, and is more aggressive and less differentiated than papillary or follicular cancers. Approximately 4 percent of all thyroid cancers will be of the medullary subtype. These cancers are more likely to spread to lymph nodes and other organs, compared with the more differentiated thyroid cancers. They also frequently

Most are common only around 5% coming to be cancerous. Most times when a person has a thyroid nodule they have no symptoms. If the nodule is causing your glands to make too many hormones it can cause what is called hyperthyroidism. Symptoms of this include palpitations, rapid heart rate, anxiety, restlessness and an increased appetite. If your doctor suspects thyroid nodules they will do tests such as an ultrasound or a thyroid scan. A good example of a procedure done by an endocrinologist is an LHRH test. This test is done to see how your pituitary gland is working when it comes to regulating sex hormone production. The night of this procedure you are to not eat or drink anything. When you go in, you will be made comfortable and have a small needle inserted into a vein in your hand or arm. This is just to get a blood sample and is not to stay. Whoever is taking the blood will use a needle such as a ventflon to make drawing the blood sample easy with little to no discomfort. The blood is then checked for hormones LH and LSH then you get an injection to make the levels of those hormones rise. You will have blood drawn twice. Once each after 30

If you were to get thyroid cancer there is an 80% chance that you would get Papillary thyroid cancer. Women have a higher chance of getting the thyroid cancer than men (there is a 3:1 ratio). In over 50% of the cases of Papillary thyroid cancer, it is common for the cancer to spread to the Lymph nodes, (which are located in the neck region), although it is uncommon This type of thyroid cancer is typically caused by exposure to radiation.

Follicular tumors, on the other hand, grow only on one side of the gland. These tumors develop in the hormone-producing cells and account for 30% - 50% of all thyroid cancers (Thackery 1057). Medullary thyroid tumors account for 5% - 7% of all thyroid cancers, and are usually uncommon. Like papillary tumors, they grow on one or both sides of the gland. Anaplastic tumors, though extremely rare, develop on either side of the thyroid gland and spread rapidly to other parts of the body. It account for only 2% of all thyroid cancers but is the fastest growing, and most aggressive thyroid cancer type (Thackery 1057).

What is thyroid cancer, and is it dangerous? To answer this one must first know the function of the thyroid. A thyroid is a gland at the front of the neck right under the sound box, which secretes hormones that affect heart rate, body temperature and weight. It also makes calcitonin, which keeps a healthy level of calcium in the body. Thyroids are made up of tissue, when the cells that make up the tissue of the thyroid gland start to form unnecessarily, and cells that are damaged are not killed, tumors called nodules form on the thyroid thus resulting in cancer. Around 45,000 women and 15,000 men were diagnosed with thyroid cancer in 2013 alone, most of whom were above the age of 45. However getting thyroid cancer is not the worst thing in the world as it is treatable but there should still be more investment and research put into this disease so that less risky methods of taking out the cancer can be found.

Your health care provider may also suspect a thyroid nodule based on your symptoms. You may also have tests, including:

Most thyroid tumors can be readily diagnosed using histopathologic criteria, which allow the pathologist to differentiate benign from malignant lesions and guarantee an accurate classification for the majority of the variants of carcinomas derived from follicular epithelial cells. However, in most cases, the pathologist is confronted with thyroid lesions in which the distinction between benign and malignant can be quite subtle. The decision favoring one or another has clinical consequences and implies different modalities of treatment. For this reason, the approach to these challenging tumors should include ancillary techniques, immunohistochemistry and molecular profiling, that can improve the standard morphologic assessment (3).

There are many causes of hyperthyroidism, but the symptoms of hyperthyroidism are the same no matter what causes the over expression of thyroid hormones. The main symptoms of hyperthyroidism are fatigue, shortness of breath, weak muscles, anxiety, difficulty sleeping and heart palpitations. Interestingly, even with an increase in appetite the patient will have weight loss.

Prior to the physical examination of the thyroid gland the examiner should as about any recent infections or tenderness in the neck (Jarvis, 2015). Ask if there have been any lumps or swelling noted in the neck (Jarvis, 2015). You would ask if there has been a history of thyroid problems and if so how has it been treated in the past (Jarvis, 2015). And lastly ask if there has ever been any surgical procedures or irradiation of the neck or neck region (Jarvis,

The differentiation of single benign nodule and malignant one is considered an important goal. Early diagnosis of thyroid cancer avoids unneeded surgery in those complaining of benign nodules and decreases both mortality and morbidity rates of the disease (2).