Treatment Of Diabetes Mellitus ( T2dm )

1551 WordsDec 8, 20147 Pages
Date and Time requested: November 23, 2014; 8:00 AM Date and Time responded: December 8, 2014; 8:00 AM Drug consult request: Does canagliflozin compared to glimepiride provide an efficient and safe add-on therapy to metformin for uncontrolled type 2 diabetic patients? Background Type 2 Diabetes Mellitus (T2DM) is a lifelong progressive disease with increasing prevelence.1,2 It is the most common form of diabetes (90-95% of diabetic patients) and requires continuous medical care.1,2 For most T2DM patients, metformin is considered the first line of pharmacological treatment in addition to proper diet and exercise.1,2,3 Long-term glycemic control is a common challenge in T2DM patients due to progressive nature of the disease and often a combination of add-on therapies are required. 1,2,3 Sulfonuylurea, insulin secretagogues, including glimepiride are common add-on therapies to metformin for the management of T2DM.3 The mechanism of action of glimepiride primarily involves stimulating insulin release from pancreatic beta cells.3 Although glimepiride might be considered effective as add-on therapy to maintain glycemic control, it has the propensity to induce hypoglycemia and weight gain. 3 Overall, a considerable portion of T2DM patients suffer from worsening glycemic control over time, intolerance, hypoglycemia and weight gain with present combination therapies.3,4,5 Pharmacologic agents with complementary mechanism of action such as SGLT2 inhibitors might present a unique

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