Treatment Of Pituitary Gigantism Is A Rare Endocrine Disorder

Benjamin is a 12-4/12 year old boy with Velocardiofacial syndrome, who has been followed for quite some time. Benjamin presented with concerns of micropenis, as well as growth failure. As you can see from the attached penile growth curve Benjamin does in fact have a micropenis with a measurement that is significantly below the normal curve. With respect to his height, he was monitored and fell from 50% to just above 10% on the growth curve. He subsequently underwent growth hormone stimulation testing which he failed with a peak growth hormone response of 2.4ng/ml. Clearly, the failed growth hormone stimulation test and the micropenis are consistent with diagnosis for growth hormone deficiency.”

A goiter, nodules, or growths may be found during a physical exam, and symptoms may suggest hypothyroidism.

In the medical world, there is a variety of genetic disorders that affect many people. One of which is Pituitary Dwarfism. Dwarfism is a rare genetic disorder that includes the underdevelopment of the body. Specifically, Pituitary Dwarfism is a rare form of Dwarfism that is caused by the absence of a functional anterior pituitary gland which is located in the brain. It does not release the growth hormone GHRH needed for proper development. Although this mutation does not affect many people, the patients that do carry this genetic disorder are greatly affected. The diagnosis of this disorder is a fairly simple process involving a blood test and an analysis of the patient’s growth compared to a person with normal alleles. These people have life-changing

The causes of hypopituitarism in the adult are represented by: pituitary tumors (54%), craniopharyngioma (12%), tumors of the central nervous system (4%), empty sella syndrome (4%), syndromes of Sheehan (3%) , and more rarely by trauma, ipofisiti, surgical iatrogenic causes, granulomatous diseases, radiation, CNS malformations,

This region produces hormones that control other structures in the endocrine system. The amount of these regulatory hormones remains almost the same, but the response from the endocrine organs can change as we get older. The pituitary gland is also located in the brain. This gland reaches its maximum size when people reach middle age and then gradually becomes smaller.

Pseudohypoparathyroidism is a genetic condition so rare that only seven out of one million people are diagnosed with it each year. In hospitals if there have been patients who have different physical appearances than normal or any other symptoms (Enrichment 1), a doctor can diagnose them with different types by their physique differences or how their body looks and reacts. Sometimes if patients happen to have no symptoms of divergence at all, doctors and their colleagues can diagnose the with much research and blood work. The condition was first discovered in the early 1940’s when endocrinologist Fuller Albright and his colleagues figured out after much researching and experimenting that a group of patients who were experiencing skeletal

There are mainly two types of hypothyroidism in adults, primary hypothyroidism and secondary (central) hypothyroidism. In primary hypothyroidism, the thyroid tissue gets affected and losses functionality leading to diminished production of TH. Some causes of primary hypothyroidism are endemic iodine deficiency, autoimmune Hypothyroidism (Hashimoto’s thyroiditis), loss of thyroid function due treatment of hyperthyroidism, medications and radiation therapies around head and neck. On the other hand central hypothyroidism is caused by pituitary malfunction and hypothalamic malfunction. Congenital hypothyroidism occurs in newborns where they lack the presence of thyroid gland or has genetic disorder in TH synthesis. If not identified and treated this can severely effect child’s

Megan would most likely be treated for her condition with growth hormone since growth hormone-releasing hormone is being released from the hypothalamus in levels within normal range, and hence should be releasing growth hormone. This means the problem lies within the pituitary gland which is the location where growth hormone is being released from.

Endocrinologic consultation is advised for further work-up and management if there are more endocrine cases involved

Acromegaly is a disorder involving the hormones when the pituitary gland puts out too much of the growth hormone (GH) during adulthood. This results in noticeably enlarged bones and extremities. Acromegaly is actually the Greek word for “extremities” and “enlargement”, resembling the most common symptoms. It is an uncommon disorder affecting mostly middle aged men and women and occurs in about 6 in every 100,000 adults.

The symptoms of Hypothyroidism: Swollen neck, brittle nails, coarse hair, hair loss, weight gain, intolerance to cold/heat, irregular menstrual, fatigue, depression, skin disorders, puffy face, constipation and numbness of limbs. If you are experiencing any of these symptoms you should consult with you physician about a diagnosis.

Surgery on the pituitary gland and around the sellar region is of special interest to the neurosurgeon. The approach to the gland has evolved over the past 50 years and so has the role of steroids in the perioperative management of these patients. Being one of the organs that play a key role in the hormonal balance of an individual, the neurosurgeon should be particularly careful that all steps must be taken to optimise the hormonal status and also ensure there is no disruption in that balance postoperatively. For more than half a decade the meticulous administration of steroid perioperatively has become common place. Today, however, the old philosophies are being challenged and new philosophies pioneered creating a paradigm shift in the way we manage patient requiring an operation around the sellar region, in particular pituitary surgery.

Acromegaly is a rare disease mainly caused by pituitary adenomas resulting in the hypersecretion of growth hormone. Most individuals develop skeletal, tissue and organ growth abnormalities. The severity and onset of symptoms are dependent on how long the disease has been manifesting. Often, acromegaly is undetected or misdiagnosed until the later stage of the disease since the symptoms are subtle and gradually appear. Diagnostic tests can be used to confirm the prediction of acromegaly. Elevated growth hormone and insulin like growth factor 1 levels in the blood are the key indicators of confirming acromegaly. Currently, there are three treatment options for patients: surgery, radiation and medication; the former is the method of

Growth hormone fuels childhood growth and helps maintain tissues and organs throughout life. It's produced by the pea-sized pituitary gland — located at the base of the brain. Beginning in middle age, however, the pituitary gland slowly reduces the amount of growth hormone it produces.

Gigantism disease is caused by a brain tumor in the pituitary gland. Since this gland is responsible for the production of the growth hormone, a tumor in this gland can trigger abnormalities in this hormone’s production which can cause gigantism. The tallest person in the history had gigantism who is called Robert Wadlow. His height was 272 cm.