Treatment of Diabetis Type 2: Classical Oral Antihyperglycaemic Agents

Catechin has been shown to modulate the hepatic microsomal phospholipase A2 activities. It can change the hepatic phospholipid species in streptozotocin-induced diabetic rats [78]. On the other hand epigallocatechin gallate, a constituent of green tea, represses the hepatic glucose production. EGCG also mimics insulin by increasing phosphoinositide 3-kinase, mitogen-activated protein kinase. Furthermore, EGCG has been shown to regulate genes that encode gluconeogenic enzymes and protein-tyrosine phosphorylation by modulating the redox state of the cell. These finding suggest that EGCG, or derivatives can perform as antidiabetic agent [79]. Green tea has also been shown in vivo to down regulate the hepatic gluconeogenic gene-expressions of enzymes. The results of this study support the idea that green tea intake may be favorable in the prevention of diabetes mellitus [80]. Diabetes is multi-causal disease. Even the onset of the disease is caused by a single factor but its progression and pathogenesis may be attributed by a number of confounding factors. So, in some

This indicates that the metabolism of proteins was apparently affected by Ch.t extract. The improvement on the levels of protein and albumin in the diabetic treated groups show that Ch.t extract have significant effect in glucose and protein level because insulin inhibit gluconeogenesis from protein [ ] or could be due to improvement in renal function. This affirmative agrees with the fact that the weight of skeletal muscles was significantly increase in diabetic rats treated with Ch.t extract. The decrease in albumin level documented for diabetic rats may be due to liver massive necrosis, deterioration of liver function, hepatic resistance to insulin and glycogen impairment of oxidative phosphorylation[ ].Under the same experimental conditions serum globulin level revealed an appreciable decrease[ ]. The renal pathogenesis is related to duration of diabetes, the most devastating complication with diabetes is nephropathy[

It has been discovered for a very long time that certain genes are responsible for the development of type 2 diabetes, however, efforts to find a suitable agent that can turn off those genes were successful. The good news now is that some phytonutrients that can turn off all the genes have been discovered. Awesome! You aren’t going to be addicted to pills like before.

Considerable advances in the past treatment of type II diabetes include the application of lifestyle intervention and prevention efforts aimed at delaying development of glucose intolerance in order to evade diabetes and the progression of new curricula of glucose in the blood-lowering prescriptions to appendage current treatments (DeFronzo, 2010) (Mazzola, 2012). Presently, the control and maintenance of type II diabetes centres on control of glucose by the decrease of haemoglobin and glucose in the blood (DeFronzo, 2010). Current treatment strategies focus on the progression of therapeutic factors that affect the defects contributing to type II diabetes and thus, provide sustainable glucose control through a delaying of disease development

The evidence suggests the diabetic epidemic is caused by an increased overload of toxins within a person’s body. A primary goal for naturopathic doctors in the treatment of their patients is to eliminate

OLE significantly improved renal functions and prooxidant and antioxidant balance in gentamicin-induced nephrotoxicity in rats [18].

Diabetes directly caused 1.5 million deaths in 2012(Global reports on diabetes, WHO, 2016). Diabetes is a result of improper functioning of carbohydrate and lipid metabolism resulting in resistance to the insulin being produced by the pancreas which finally results into higher blood glucose levels. It can further lead to many complications such as retinopathy, hyperlipidemia, atherosclerosis, hypertension, neuropathy and nephropathy if not managed. There is strong evidence suggesting that T2DM is a result of failure of beta-cells in the pancreas. It starts as a decrease in the response by the peripheral tissues to insulin (insulin resistance) and gradually affects the functioning of beta-cells of pancreas, finally resulting in severe destruction of the cells and hence there is little or no insulin production in the body which results in impaired glucose tolerance and elevated blood glucose levels[1]. Controlling diabetes involves changes in dietary habits, exercise and use of conventional medications. However, traditional medicines can have adverse side effect and can be expensive. Lot of investigations continue to be done to check the efficacy of natural medicinal herbs and spices to manage a whole range of diseases including diabetes

The anti-inflammatory properties of the Moringa plant helps circulation. Many anti-inflammatory medicines prescribed to diabetes patients have nasty side effects, but with the Moringa Olefera plant, there are no negative side effects, meaning it’s a completely safe way for people to manage their

Diabetes Mellitus is a prevalent disease that spreads world wide, adversely affecting the lives of millions. The term “mellitus” encompasses the various types of diabetes. As a whole, Diabetes Mellitus is a group of metabolic conditions in which there are prolonged periods of time where blood glucose levels are way above normal volumes. Type 1, Type 2, Type 3, and Gestational Diabetes are the principal variations of Diabetes Mellitus. Despite the particular prominent cause differentiating these types, each of them stem from the issue of hyperglycemia due to the insufficiency or resistance of the hormone, insulin. Fortunately, new research regarding nutrition therapy has alleviated much of the worry surrounding diabetic diets, subsequently

One of the best natural remedies that help diabetes may already be in your kitchen. Cinnamon will be a great way to mimic the effects of insulin in the body. You can take this as a

Diabetes mellitus is a chronic disorder caused by insulin deficiency that may be partial or complete, resulting in hyperglycaemia leading to acute and chronic difficulty. The frequency of diabetes mellitus is on rise all over the world. The dominance of diabetes has and will continue to have burden on health and finances of economic climates, which in turn, will put impact on persons, families, and nations.(food research international, vol.44(4):862-867) Control of plasma glucose concentrations is essential to reduce the incidence and brutality of long term diabetes effect. Synthetic drugs are likely to give serious effects in addition they are not suitable for eating during situation like pregnancy. Apart from conventional diabetes

Diabetes characterized by high blood sugar level, increased hunger and thirst and frequent urination is fundamentally of two types. They are Diabetes insipidus and Diabetes mellitus (Type-I and Type-II). Type-1 diabetes is also known as insulin-dependent diabetes or juvenile diabetes. This means your body cannot produce enough insulin to metabolize starch and sugar from your food into an energy source due to the lack of pancreatic hormone insulin. It is more prevalent among young adults and children. In case of Type 2 diabetes, your body produces insulin but the cells are not able to utilize it well. Hence this condition is as termed as insulin resistance. Here, regular supplementation of insulin

“A 2012 review of several recent studies concluded that the use of cinnamon had a potentially beneficial effect on glycemic control” (Castro). Like many other herbal remedies, more research needs to be conducted to provide addition proof for the anti-diabetic properties of cinnamon. Scientists have actually discovered five major ways that cinnamon can benefit diabetics. The first is that cinnamon can significantly increase metabolism of glucose, which aids in blood sugar regulation, something very essential to diabetic individuals. Cinnamon in the future may act as an insulin substitute because of its many “insulin-like

and 8 weeks of streptozotocin (STZ)-induced diabetes in rats and the effect(s) of ginger (500 mg/kg/day).

Lo C, Toyama T, Hirakawa Y, Jun M, Cass A, Hawley C, Pilemore H, Badev SV, Percovic V, Zoungas S. Insuline & Glucose lowering agents for treating people with diabetics and chronic Kidney disease. Cochrane Database of systematic reviews 2015, Issue 8. Art. No. CD011798. DOI:10.1002/14651858.CD011798.