Trend of Malaria in Odisha

Malaria has been in existence for thousands of years. Many historical records show that it has affected human civilization greatly by plaguing and causing mass death. The earliest record can be traced back to 2700 BC in China (Cox, 2002). It has been long associated with swamps and insects for hundreds of years but often believed to be the air from swamps causing the plague. The term malaria rooted from two Italian words ‘mala’ and ‘aria’ which literally means bad air. Humanity did not know the true nature of the long thought disease until 1894 when a Scottish physician, Sir Ronald Ross, discovered that it was actually the parasite in mosquito that is causing the malaria.

Malaria is blood disease caused by a parasite called Plasmodium. This disease occurs widely in poor, subtropical and tropical regions of the world. One subtropical region that has been greatly affected by this disease is Sub-Saharan Africa. According to Olowookere, Adeleke, Kuteyi, and Mbakwe (2013) malaria is one of the leading causes of death and illness in sub-Saharan Africa. It is important to be aware of the impacts this disease carries and how it has greatly affected millions of people. This paper will explain the impacts of Malaria and discuss, compare, and contrast the malaria research conducted by various researchers and reflect on the issue.

Malaria has been a major life-threatening disease for thousands of years, and continues to threaten millions of lives around the world. It infects approximately 219 million people each year, mostly poor women and children. What is striking about malaria is the fact that it has the worse effect on those with the least ability to fight the disease. The Republic of Cuba believes that malaria prevention, treatment, and research efforts must be accelerated to eliminate the burden of this disease across Africa, Asia, the Americas, and any country or territory at risk of malaria transmissions.

Brian, G, Y., Greenwood, D, A., Fidock, Dennis, E, K., Stefan, H, I. Kappe, P., Alonso, L., Frank, H and Collins, P (2008) “Malaria progress and prospects for eradication.” Journal Clinical Investiment. 118: 1266-1276.

Malaria (also called biduoterian fever, blackwater fever, falciparum malaria, plasmodium, Quartan malaria, and tertian malaria) is one of the most infectious and most common diseases in the world. This serious, sometimes-fatal disease is caused by a parasite that is carried by a certain species of mosquito called the Anopheles. It claims more lives every year than any other transmissible disease except tuberculosis. Every year, five hundred million adults and children (around nine percent of the world’s population) contract the disease and of these, one hundred million people die. Children are more susceptible to the disease than adults, and in Africa, where ninety percent of the world’s cases occur and where eighty percent of the cases

Background - Malaria is a water borne disease. It is spread by a parasite-carrying mosquito. It kills many people and reduces a country 's capacity to develop. There are different strategies to combat malaria. Around half the population is at risk of malaria and this disease is active in 106 counties across Africa, Asian and the Americas (see source 3). the global annual mortality from malaria is between 1.5 - 3 million deaths, or between 4000 and 8000 each day. Developing countries are most vulnerable to Malaria and as shown on source 2 Malaria has been spread across many various other countries including in Europe, but these countries have eradicated Malaria.

Malaria is a disease that affects nearly 600 million people and causes more than a million deaths a year, the most coming from children under five. This disease is regularly found in more than 100 countries around the world and affects 40% of the world’s population. It is most commonly transmitted by an infected Anopheles mosquito. The most deadly form of malaria is known as Plasmodium falciparum because almost all deaths from malaria are caused by this specific one. Some of the symptoms that are affiliated with this strand of malaria are the destruction of red blood cells along with complications with the kidneys, lungs, and brain. In more serious cases, it can cause permanent neurological effects and even death. As the Nobel Assembly said at the announcement of the Nobel Prize in Physiology or Medicine, “Diseases caused by parasites have plagued humankind for a millennium and constitute a major global health problem. In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing”. Youyou Tu, one of the winners of the prize, discovered Artemisinin, “a drug that has significantly reduced the mortality rates for patients suffering from malaria by killing the malaria parasites an early stage of their development.”

Malaria has been a huge problem among many developing nations over the past century. The amount of people in the entire world that die from malaria each year is between 700,000 and 2.7 million. 75% of these deaths are African children (Med. Letter on CDC & FDA, 2001). 90% of the malaria cases in the world are located in Sub-Saharan Africa. Once again, the majority of these deaths are of children (Randerson, 2002). The numbers speak for themselves. Malaria is a huge problem and needs to be dealt with immediately.

Fortunately this may all change as for the first time there is talk of wiping out malaria, mostly if not entirely from human existence. To first understand how this is possible, we must first discuss why is malaria, such a big problem and why is it so efficient in what it does. Malaria is commonly found parasites, including Plasmodium falciparum, P. vivax, P. ovale, and P. these parasites commonly infects mosquitoes which feed off of the blood of various animals including humans. Interestingly, only female mosquitos are able to host the parasites needed to spread malaria. When the mosquito puncture people with their hypodermic like nose to drink the blood, typically a bit of the blood is regurgitated and when this is done, some of the mosquito spit is also put back into the person. In the spit exists the parasites which are responsible for the symptoms of malaria. Once the parasites are in the body, they will begin to make their way to the liver and eventually infect a large amount of liver cells until the parasites are mature. Once some of the parasites are mature, some will enter the bloodstream while others will remain dormant within the liver to ensure that not all of the parasites are

Also, human population movement from higher transmission areas jeopardizes reintroduction and resurgence in malaria-free regions, and in addition has undermined elimination works in the past. For that reason, it is important to understand the patterns of parasite dispersal in order to target control by pinpointing regions where the imported infections originate from and where they play a part in transmission.

Malaria is considered the most important vector-borne infectious disease in the world, which is caused by a species of the Plasmodium parasite, and transmitted by female Anopheles spp mosquitoes.2,10,12

In 2015, approximately 3.2 billion people, which is almost half of the world 's population, were at risk of being infected with Malaria. Most cases of malaria occur in sub-Saharan Africa however, Asia, Latin America, and, the Middle East are at risk but to a lesser extent. In 2015, 95 countries had relentless malaria spread, around 88% of the cases and 90% of deaths where in Africa. The pattern between most countries is that they are low or middle income countries. Those who do not have access to proper health care are the ones who are most affected by the disease. Even in sub Saharan Africa the three countries with the highest death from malaria are among the poorest in the region. The high cases and death rates in Africa is caused by different reasons.

Malaria affects hundreds of millions of people per year, and in 2013, caused an estimated 584,000 deaths, the highest burden of which occurred in Africa (World Health Organization, 2014a). It is a vector borne illness that is transmitted to humans by being bitten by malaria carrying female anopheles mosquito (World Health Organization, 2014b). Of the approximately half of one million people who die each year of malaria, 78 % of these are children under the age of five, placing them as one of the highest risk groups for malaria (World Health Organization, 2014a). It is essential that the recognition and treatment of a child with malaria happen quickly and efficiently because children have a high risk of rapid disease progression, which if

About 3.3 billion people, that is about half of the world’s population are at risk of contracting malaria (figure 1). Every year there are 250 million cases of malaria, and nearly 1 million deaths. That amounts to 2,732 deaths per day. Out of those million people that die every year, 800,000 of them are African children under the age of 5. To control malaria three actions need to be taken: insecticides need to be used to decrease the vector population, people have to be educated as to how to prevent the vector from reproducing, and anti-malarial drugs need to be distributed. To understand the vector and what the vector is, scientists had to first discover what the parasite was and how it worked. It was not until the year 1880 that French Physician Charles Laveran discovered that Malaria was caused by a protozoan in the genus Plasmodium (Malaria, 2013)

Plasmodium species (sp.) is the caustic protozoan parasite known to cause malarial disease. One of the most common disease in tropical and subtropical regions of the world is malaria, causing 500 million malarial infections with 1-2 million deaths per year (Tangpukdee, Duangdee, Wilairatana, & Krudsood, 2009, p. 93). In addition to the severity of the disease is dependent on the species of Plasmodium acquired by the patient with P. falciparum being the most severe and fatal while P. vivax, P. ovale, P. malariae and P. knowesi cause acute disease that is rarely fatal. Furthermore, the number of malarial cases seems to be increasing due to drug resistant strains that are emerging, increased amount of travel and migration through