Introduction Trisomy 18, or Edwards Syndrome as it is more commonly known, is a genetic disorder in which there is a problem with cell division called meiotic disjunction. This disease is commonly associated with the well known Downs Syndrome which is also known as Trisomy 21. A disease with an unnatural number of chromosomes are is called a aneuploidy. Edwards Syndrome occurs when a child is born with an extra #18 chromosome. This occurs in about 1 in 2500 pregnancies and 1 in 6000 births. There is a high mortality rate for Edwards Syndrome, half of all children who are carried to term will be stillborn. With the survivors less than 10% will live to be a year old, boys also having a higher mortality rate. (Trisomy 18 Foundation 2013). In this paper I will be addressing key components to Trisomy 18 and looking more closely at a few cases of “long living” survivors. Specifically history, symptoms, diagnosis, screening and treatment will be examined.
Trisomy 18 and 13 began to appear in literature in the early 1960's. During this time both of these diseases were considered fatal. A majority of the documented information obtained on these chromosome disorders was gathered from case studies. Even to the current day, these are very deadly syndromes that often kill within the first year of life but due to medical advances can now have life sustained (Nelson 2012). In a study from 1968 some of the clinical features of Edwards syndrome include an elongation of the