Trisomy 21 Down Syndrome

Trisomy 21 is a disorder that is also considered a chromosomal abnormality because it has an extra chromosome added. This causes the abnormality to have Down syndrome. Like in most cases of Down syndrome are not inherited. When the condition is caused by trisomy 21, the chromosomal abnormality occurs as a random event during the formation of reproduction cells in a parent. The abnormality usually occurs in egg cells, but it occasionally occurs in sperm cells.

Obesity has become a normality in the states and around the world. There has been a big push on social media lately to accept all body types and stop hate and discrimination of overweight people, yet weight bias still remains one of the most prevalent and most accepted forms of bias. Typically, we associate obesity with a lack of exercise or an excess of caloric intake or just laziness on the part of the patient. However, patients who suffer from Trisomy 21, or Down Syndrome, often seem to present as obese. In fact, according to Polednak and AulifFe (1976), 20% of males with a learning disability were obese while 17% of females were obese. While this should come at no shock due to the prevalence of obesity in our society, it is a major concern.

Trisomy 21, most commonly known as Down Syndrom is a congenital chromosomal condition in which an individual possesses a complete or partial duplicate of the twenty-first chromosome;whereas, the typical person has a total of 46 chromosomes, a person with Dien Syndrome has 47. This may not seem like a big deal, but this disorder results in varying degrees of mental

Down syndrome is caused by having an extra chromosome on the twenty-first chromosomal pair. People with down syndrome have forty-seven pairs of chromosomes. There are three types of down syndrome and they are Trisomy 21, Translocation, and Mosaicism. Trisomy 21 is the most common type of down syndrome. It occurs when there are three rather than two, number 21 chromosomes present in every cell of the body. Trisomy 21 accounts for ninety-five percent of the down syndrome population. Translocation unlike Trisomy 21 only accounts for four percent of the down syndrome population. In this case, part of the twenty-first chromosome breaks off during cell divas and attaches itself to another chromosome, usually chromosome 14. Mosaicism is the rarest

Genetic testing is a medical test that can find and identify changes in proteins, genes or chromosomes. Using a genetic test can confirm or deny a suspected genetic condition, as well as to help determine a person who is possible of carrying on a genetic condition.(NIH, 2016)

Down syndrome (also known as trisomy 21) is a disorder that makes you physically and mentally more challenged than everyone else but you are still able to grow develop and live a partially normal life. The major causes of Down syndrome are first just getting unlucky and having the 21st chromosome be irregular. But if you have a child when you are older than 35 you have a highly increased chance of getting down syndrome also if you have a sibling with Down syndrome or another kid with-it that can also increase the chance of getting down syndrome. Some symptoms of this disorder are, you can be physically less capable than others can and can have a hard time remembering things and can possibly not be able to achieve what seems to be easy things to do daily. However, most important, they only live to about 80. In addition, they can have a hard time reproducing but can still can reproduce.

Trisomy Down Syndrome happens when there are three 21 chromosomes as opposed to the normal two. This is a result of either the sperm or egg failing to separate causing a replication in every cell of the body. Another type called Robertsonian Translocation happens when part of chromosome 21 is translocated to another chromosome to the reproductive cells to the parent or early development of the child. This type accounts for about 4% of all cases of down syndrome. Mosaic is a form of down syndrome when the extra chromosome 21 is found only in some of the body's cells. “Mosaicism is the least common form of Down syndrome and accounts for only about 1% of all cases of Down syndrome.”

There are 23 pairs of chromosomes in a normal human cell. Trisomy 21 or Down syndrome occurs when there is a third copy of chromosome 21 and causes malformation in body and brain development. Giving birth to a child with down syndrome increases as the mother ages. The odds of having a child with trisomy 21 are 1 in 1000 for women under the age of 35. This increases to 1 in 200 for women 35 and older. Thus, while not completely avoidable, it is best to have children while the mother is still under 35 to allow the child to be less likely to be born with down syndrome.

Trisomy 21 most commonly known as Down syndrome is a genetic disorder that causes abnormal cell division resulting an extra genetic material forming a twenty-first chromosome. No one knows for sure why Down Syndrome happens and there is no way to prevent the chromosomal error that causes it. Scientists knows that women age thirty-five and older have a significantly higher risk

Marisna is a 39yo, G3 P2002, who is currently 21 weeks 0 days as dated by LMP using a due date of 04/25/17. This was consistent with her 1st ultrasound in your office that measured just slightly ahead with a due date of 04/18/17. She is AMA. She had a quad screen in your office that returned screen positive with an increased risk of Down syndrome of 1:100. This is close to what her age based risk would be. Open neural tube defect was screen negative. In reviewing her analytes, AFP was slightly elevated at 2.15 MoM and inhibin was borderline at 1.87 MoM. She was diagnosed with chronic HTN fairly early in her last pregnancy. She did not have preeclampsia with that pregnancy to her knowledge. The baby was quite small, as it weighed just over 4 lb at term. She was not on BP medication chronically, but coming into this pregnancy at 19 weeks her BP was elevated at 162/90 and she was started on labetalol. I cannot tell in the records if she had protein in her urine but she did have 2+ on her dip in our office today. She reports that she has collected a 24-hr urine last week, although we do not have those results. Because she entered care late, she is not on baby aspirin for the prevention of preeclampsia.

Down syndrome is characterized by three different types: trisomy 21 (nondisjunction), translocation, and mosaicism. The cause of Trisomy 21 is

There are 3 types of Downs syndrome, translocation; standard trisomy 21 and mosaicism. Translocation is caused when a piece of chromosome 21 is located on another chromosome such as chromosome 14. The person with Translocation Trisomy 21 will have 46 chromosomes but will have the genetic material of 47 chromosomes. The person with Translocation Trisomy 21 will exhibit all the same characteristics of a person with Standard Trisomy 21 since they have three copies of chromosome 21. Translocation occurs between 3% and 5% of cases of Down syndrome. Standard trisomy 21 is the most frequent form of downs syndrome. Those affected by trisomy 21 will have 47 chromosomes in every cell as opposed to 46 like normal. Mosaicism is similar to standard trisomy

Down syndrome (known as Trisomy 21) is a genetic disorder caused when cell division results in extra genetic material from chromosome 21. This genetic disorder occurs in about 1 of 800 live births. Down syndrome was first characterized a separate form of mental disability by John Langdon Down in 1862. By the 20th century the disability had become the most recognizable form of mental disability. These individuals have gone through a lot. In ancient times, many infants with this disability were killed or abandoned. The people with Down syndrome used to be called Mongolian idiots and the syndrome was called mongolism. This comes from the people thinking that Down syndrome individuals resembled Mongolians. It doesn’t only affect the individual

Down syndrome is a chromosomal condition that affects 1in every 700 kids. Down syndrome is when a child has and extra copy of chromosome 21. Down syndrome has many ways of telling if the child has down syndrome, like physical features. You can also tell if a child has down syndrome based on how they act. There are different ways of obtaining down syndrome. Kids with down syndrome are no different than kids that were born with the normal set of chromosomes, they just act a little different and need a little bit more help.

     Mosaic Trisomy 21 happens when an egg or sperm come in with an extra copy of chromosome 21, then,