Tuberculosis And Its Effects On The Human Body

Tuberculosis has long been a disease that the human culture has been dealing with which entails significant morbidity and mortality worldwide. With dealing with such a horrific disease over the years, discoveries and evolution on the appropriate ways to contain, diagnose, and challengingly treat the disease has changed. One of the most concerning complications of this worldwide public health issue is the ability for it to quickly spread in high populated areas while becoming ever more resistant to forms of treatment not available in all locations around the world. This is a serious public

According to the book, Know about Tuberculosis, scientists dicovered tuberculosis was the most contauious disease in Egypt that led to spreading to other countries. Columbus and European explorers were blamed for being tuberculosis to the New World.Scientists also noticed that the bones of Egyptian mummies had been damaged, as a result of tuberculosis. Records show that one in five deaths occurred by the middle of the seventeenth century, even millions of people died in British Isles, Europe, North and South America

Bacterial pathogen Mycobacterium tuberculosis causes tuberculosis a complex granulomatous disease which is a global health concern. It is a very slow growing bacteria, thus is extremely time consuming to culture in laboratory. It can survive the attack of the immune arsenal of our body; can successfully hide inside the macrophage. This makes long periods of uninterrupted antibiotic treatment necessary for the patients with tuberculosis and contributes to drug resistance very quickly [WHO 2014]. All this poses an extreme challenge to the scientists and the medical community to develop effective drug, monitor and treat this disease across globe. Before the discovery of anti-tubercular drugs, this disease was one of the most dreaded diseases. In absence of any drugs the only form of treatment recommended was healthy diet, rest and fresh air. Patients were sent to Tuberculosis sanatorium hoping that they might survive. The origin of this pathogen is traced back to Africa around 70,000 years ago and they successfully coevolved with humans as they migrated out of Africa and settled across the globe. Nearly 10,000 years ago there was a sudden change in human demography and the human population density increased suddenly, this is termed as Neolithic Demographic Transition. Genomic data of Mycobacterium across

Many people take breathing for granted, some never give it a second thought until a problem presents itself. Respiratory diseases affect millions of Americans as well as people from all over the world. Anyone can suffer from these disorders to include men, women, and children, with conditions ranging from mild, moderate, to chronic in nature. This paper will focus on one of the many respiratory disease called mycobacterium tuberculosis; more commonly referred to as TB.

“Tuberculosis (TB), a multisystem disease with myriad presentations and manifestations, is the most common cause of infectious disease–related mortality worldwide. Although TB rates are decreasing in the United States, the disease is becoming more common in many parts of the world. In addition, the prevalence of drug-resistant TB is increasing worldwide. TB is caused by M tuberculosis, a slow-growing obligate aerobe and a facultative intracellular parasite. The organism grows in parallel groups called cords (as seen in the image below). It retains many

Tuberculosis has been part of human history for a long time but how long is a long time? Recent research using genetic data has allowed us to know that the tuberculosis progenitor has been on this planet for about 3 million years affecting even our earlier ancestors (Gutierrez et al, 2005). Additionally this research showed that the bacilli from tuberculosis are capable of mixing sections of their genome with other strains and giving the pathogen a composite assembly, which resulted from ancient horizontal exchanges before its clonal expansion. This quality provided tuberculosis a big advantage that even now a days allows the organism to evade, adapt and create resistance to treatments that were once successful. In order to fix current and

Tuberculosis, the white plague as used to be called once upon a time is still one of the deadliest bacterial killers affecting almost all parts, all corners of the globe. Though successful anti-tubercular antibiotic regimens and effective vaccine are available for decades and being used in the battle against Koch’s bacillus, Mycobacterium tuberculosis, the causative agent of this chronic multi organ granulomatous disease, our strand in the battle continuously seems to be in the losing side. Moreover the increasing prevalence of HIV-AIDS and diabetes mellitus is being proved to be providing predisposition to tuberculosis. As witnessed by the WHO, which has estimated that, in the year 2012, 8.6 million people have developed tuberculosis and 1.3 million have died of the disease including 320000 deaths of HIV-TB co-infected people (Global tuberculosis report 2013. World Health Organization; 2013). Long term antibiotic therapy and that too associated with several side effects and discomforts have diminished patient compliance with the anti-tubercular chemotherapy. This fact in turn has raised the new deadlier MDR-TB and XDR-TB strains. The whole scenario is a matter of panic and questioning the effectiveness of anti-tubercular antibiotics, immunologic efficacy of century old BCG vaccine and all other medical advents.

TB is a major cause of mortality and morbidity globally that boils down to one small, single infection. TB can be classified into 2 stages; Latent TB and Active TB. In Latent TB, the bacteria remain in the body in an inactive or dormant state. A person will not have any symptoms because their immune mechanism has stopped the bacteria from growing. Latent TB can remain in a dormant state for year (Zager et al, 2009). However this disease can easily change to Active TB. This change mainly occurs due to the rapid increase of Mycobacterium TB within an individual when a person becomes ill or their immune system is compromise. Ninety percent of the time, those who are infected with

Tuberculosis (Mycobacterium tuberculosis), also known as TB, is a disease spread by respiratory inhalation of droplets that contain the bacteria. Tuberculosis is an ancient disease that has been traced back at least 9000 years. In 1882, Dr. Robert Koch was the first physician to describe Mycobacterium tuberculosis as the germ responsible for tuberculosis. However, treatment that was evidenced based was not put into practice until the 20th century. It is estimated that 2 billion people around the world are infected with the TB bacteria. Approximately 5 to 10 percent of these infected people will actual develop active TB and experience the life-threatening symptoms of the disease. Tuberculosis

Tuberculosis is a disease cause by a bacterium that spreads when a person infected with the virus, sneezes, coughs, or even talks and the germs make it into the air for another person to breathe. This bacterium primarily affects the lungs and prevents the proper functioning of the respiratory system. Tuberculosis continues to be a problem in the United States and the problem is even bigger in developing countries such as India where they have seen the growth of MDR-TB cases. The following annotated bibliographies include a variety of peer review journals, a CDC website and the RX for survival video, which addresses the burden of tuberculosis in different parts of the world. The bibliographies also look at the risk factors, prevalence, mortality,

Tuberculosis is one of the major causes of death from many infectious diseases (3). Out of 9 million people who are infected with mycobacteria, about 2 million deaths occur from tuberculosis every year (3). Unfortunately, the prevalence of tuberculosis is in a continuous increase due to increased number of Human immunodeificnecy virus (HIV) patients, bacterial resistance to anti-tuberculous drugs, and growing number of recreational drug users (3). The pathogen responsible for bacterial infection, potentially causing tuberculosis, is mycobacterium tuberculosis (MTB) (2). Persons with adequate immune system can control the bacterial infection so mycobacteria remain dormant for a long time (11). In a typical tuberculous granuloma, mature

Tuberculosis is an infectious disease which causes millions of death in humans. In India approximately 500,000 deaths occurs now and then. TB is an air borne disease which is caused by Mycobacterium tuberculosis. Apart from M. tuberculosis, there are many strains of Mycobacterial species like M. bovis , M .africanum , M. microti, M. caprae , M. pinnipedi i, M. canetti and M. mungi. Together these species are known to be M. tuberculosis complex. The main target of tuberculosis is the lungs (i.e. pulmonary tuberculosis) as well as other parts of the body (i.e. systemic tuberculosis). Most tuberculosis does not cause infection which is known as latent tuberculosis (i.e. they remain in inactive form). The spread of infection is

Tubercle bacilli emerged as a pathogen from East Africa, and as people migrated so did the disease. Tuberculosis lesions contain acid fast bacilli which have been found in Egyptian and Peruvian mummies (Schlossberg page 97). From these findings, historians and microbiologists have concluded that mycobacterium is millions of years old.

Tuberculosis (TB) – an infectious respiratory disease caused by the bacterium Mycobacterium tuberculosis (Mtb), continues to be one of 21th century’s greatest public health concerns. Attempts at

Tuberculosis is among the fatal diseases that are spread through the air. It’s contagious, meaning that it spreads from one infected individual to another, and at times it spreads very fast. In addition to being contagious, the disease is an opportunist infection as it takes advantage of those with weak defense mechanism, and especially the ones with terminal diseases like HIV and AIDS. Tuberculosis is therefore among the major concerns for the World Health Organization due to its contagious nature (World Health Organization 1).