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Tuberculosis Disease Essay

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Choose the ONE best answer. 41.1. A 35-year-old male, formerly a heroin abuser, has been on methadone maintenance for the last 13 months. Two weeks ago, he had a positive tuberculosis skin test (PPD test), and a chest radiograph showed evidence of right upper lobe infection. He was started on standard four-drug antimycobacterial therapy. He has come to the emergency department complaining of “withdrawal symptoms.” Which of the following antimycobacterial drugs is likely to have caused this patient's acute withdrawal reaction? a. A Ethambutol. b. B Isoniazid. c. C Pyrazinamide. d. D Rifampin. • Correct answer = D. Rifampin is a potent inducer of cytochrome P450–dependent drug-metabolizing enzymes. The duration of action of methadone is …show more content…

b. B Peripheral neuropathy is one of the most common adverse effects seen with the drug. c. C Clofazimine may cause skin discoloration over time. d. D The risk of erythema nodosum leprosum is increased in patients given clofazimine. • Correct answer = C. Clofazimine is a phenazine dye and will cause bronzing (the skin pigment color will change color, from pink to brownish-black), especially in fair-skinned patients. This occurs in a majority of patients, and generally is not considered harmful but may take several months to years to fade after discontinuing the medication. 41.4. A 24-year-old male has returned to the clinic for his 1-month check-up after starting treatment for tuberculosis. He is receiving isoniazid, rifampin, pyrazinamide, and ethambutol. He states he feels fine, but now is having difficulty reading his morning newspaper and feels he may need to get glasses. Which of the following drugs may be causing his decline in vision? a. A Isoniazid. b. B Rifampin. c. C Pyrazinamide. d. D Ethambutol. • Correct answer = D. Optic neuritis, exhibited as a decrease in visual acuity or loss of color discrimination, is the most important side effect associated with ethambutol. Visual disturbances generally are dose related and more common in patients with reduced renal function. They are reversible (weeks to months) if ethambutol is discontinued promptly. Figure 41.1. Summary of drugs used to treat mycobacterial infections.

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