Tuberculosis Remains a Major Global Health Problem

Tuberculosis has long been a disease that the human culture has been dealing with which entails significant morbidity and mortality worldwide. With dealing with such a horrific disease over the years, discoveries and evolution on the appropriate ways to contain, diagnose, and challengingly treat the disease has changed. One of the most concerning complications of this worldwide public health issue is the ability for it to quickly spread in high populated areas while becoming ever more resistant to forms of treatment not available in all locations around the world. This is a serious public

TB is still proven to be a top killer around the world, and with more cases of drug resistant TB being reported daily, the cost of treating and preventing this disease will continue to be on the rise.

Tuberculosis is a deadly disease that is now affecting our world and the people living in it in a horrible way. Due to many factors such as poverty, HIV/AIDS, and lack of health care, many third world and developing countries have been left very vulnerable to tuberculosis. It is affecting a large part of these countries and is leading them deeper into poverty and sickness. The effort to help these countries against tuberculosis has only been slightly effective against this widespread and destructive disease.

Tuberculosis is a disease of an infectious nature caused by a bacterium known as mycobacterium tuberculosis. The disease spreads through the air. People with the disease can spread it to susceptible people through coughing, sneezing, talking or spitting. It mainly affects the lungs and other parts such as the lymph nodes and kidneys can also be affected. The symptoms for TB are fatigue, coughing, night sweats, weight loss and fever. One third of the population of the world is affected with mycobacterium tuberculosis. The rate of infection is estimated to be one person per second. About 14 million people in the world are infected with active tuberculosis. Drug resistant TB has been recorded to be a serious public health hazard in many countries. Resistant strains have developed making it difficult to treat the disease. TB has caused millions of death mainly in people living with HIV/AIDS ADDIN EN.CITE Ginsberg19981447(Ginsberg, 1998)1447144717Ginsberg, Ann M.The Tuberculosis Epidemic: Scientific Challenges and OpportunitiesPublic Health Reports (1974-)Public Health Reports (1974-)128-13611321998Association of Schools of Public Health00333549http://www.jstor.org/stable/4598234( HYPERLINK l "_ENREF_3" o "Ginsberg, 1998 #1447" Ginsberg, 1998). The World Health Organization came up with the DOTS (Directly Observed, Therapy, Short course) strategy. The approach involves diagnosing cases and treating patients with drugs for about 6-8

Once believed to be easily treated and prevented, Tuberculosis (TB) has recently been making a steady comeback. Previous to modern medicine, TB claimed millions of victims, spreading from person to person like wildfire. Around the 17th-18th centuries, the “White Plague” took the lives of 1 in 5 adults (20%) in Europe and North America (Iseman, 1994). However, as technological advances progressed, this seemingly ferocious viral disease became a primal, insignificant thing of the past. But, in the nature of all bacteria, TB has, in the recent years, mutated to become progressively drug resistant. Why is Tuberculosis coming back with a vengeance? Well, the answer’s quite simple. TB has done an amazing job of standing in the corner and

Tuberculosis, the white plague as used to be called once upon a time is still one of the deadliest bacterial killers affecting almost all parts, all corners of the globe. Though successful anti-tubercular antibiotic regimens and effective vaccine are available for decades and being used in the battle against Koch’s bacillus, Mycobacterium tuberculosis, the causative agent of this chronic multi organ granulomatous disease, our strand in the battle continuously seems to be in the losing side. Moreover the increasing prevalence of HIV-AIDS and diabetes mellitus is being proved to be providing predisposition to tuberculosis. As witnessed by the WHO, which has estimated that, in the year 2012, 8.6 million people have developed tuberculosis and 1.3 million have died of the disease including 320000 deaths of HIV-TB co-infected people (Global tuberculosis report 2013. World Health Organization; 2013). Long term antibiotic therapy and that too associated with several side effects and discomforts have diminished patient compliance with the anti-tubercular chemotherapy. This fact in turn has raised the new deadlier MDR-TB and XDR-TB strains. The whole scenario is a matter of panic and questioning the effectiveness of anti-tubercular antibiotics, immunologic efficacy of century old BCG vaccine and all other medical advents.

Often times, people in third world countries face health problems that are not experienced in first and second world countries. Diseases that do not exist in the countries such as the US anymore are still some of the leading problems in poor nations. Professor Susan Craddock from the department of Gender, Woman and Sexuality studies gave a presentation that focused on Tuberculosis, which is falls into a category of diseases called “neglected diseases”. They are called neglected because the development of vaccines and drugs to cure the diseases has decreased to about nothing. The market for these drugs is not lucrative enough for pharmaceutical companies in higher income countries to invest in research. Since the low income countries do not have the resources to carry out research for these drugs the number of neglected disease-related deaths has increased. I found the presentation interesting and enlightening especially because I am interested in the pharmaceutical field. In response to the neglected diseases, different organizations have come together to research and develop vaccines and drugs that can treat these diseases.

Among many misconceptions, tuberculosis is not a disease of the past. Tuberculosis remains a public health issue. It is estimated that one-third of the total world population is infected by tuberculosis (TB). The American lung association (2013) states, in 2011 alone there were nearly 9,000,000 new diagnosed cases of tuberculosis around the world and an estimated 1.4 million deaths because of this disease. In the United States, TB is not as common (but still a problem). In 2011, only 10,500 people reported having TB (Trends in Tuberculosis Morbidity and

Tuberculosis (TB) is a chronic bacterial infection that affects millions of people globally. It is a contagious disease that is spread through the air, and it usually affects the lungs. It is transmitted from person to person through droplets from the respiratory tract of those who are already infected with the disease. Some who are infected with the bacteria that causes TB often exhibit no symptoms, because their immune systems stop the bacteria from growing and multiplying. Those with compromised immune systems are more susceptible to developing the full blown disease which can cause symptoms that include coughing, spitting blood, chest pains, weakness, weight loss, and fever. Tuberculosis can be treated with a six to nine month course of a combination of antibiotics. If left untreated, TB will spread and can be fatal.

As this disease is most prevalent in developing countries, losing money is hugely impactful on society. The living conditions in these places are very poor, helping TB to spread faster and without having the opportunity to spend this money on cleaner water and sustainable living for its inhabitants, it leads to a global pandemic. Treatment for TB is not only costly, but also very lengthy and leads to people pulling out of the workforce for long amounts of time. This is expected in the next ten years, to cost the world’s poorest countries up to $3 trillion and is responsible for a production decrease of about 4-7% in some countries’ GDP. Tuberculosis is very threatening to society today, as treatment is very expensive for people living in these

Tuberculosis (TB) is considered to be a leading cause of infectious lung disease, and considered the foremost cause of death due to a single microorganism, Mycobacterium tuberculosis (MTB). According to the latest WHO report, there were around 9.6 million new TB cases emerging and 1.5 million deaths caused by TB in 2014. Furthermore, the number of cases with latent TB, who are asymptomatically infected by MTB, was estimated to include one third of the world population, which corresponds to more than two billion individuals. (1) The disease is further complicated with the development of drug resistance and co-infection, which sets a huge obstacle for TB treatment.

“Despite all the ghastliness in the world, human beings are made for goodness, the ones that held in high regard are not militarily powerful nor economically prosperous. They have a commitment to try and make the world a better place” (Desmond Tutu,15)- Archbishop Desmond Tutu. Strong words of hope and faith in humanity come from a man who is regarded in the same heights as Ghandi. Archbishop Desmond Tutu is a survivor of the deadly disease known as, Tuberculosis. According to the CDC, “One third of the world’s population is infected with TB” . A staggering number, but the amount of deaths from TB is even more astonishing, “1.8 million deaths in 2015” (Center for Disease Control). Most people get confused with what exactly tuberculosis even is, whether people say it’s like the flu or bronchitis, but it’s something truly life threatening. Tuberculosis is not exclusive to only one race, ethnicity, or gender, tuberculosis is able to kill anyone regardless of age. Therefore, it is important to raise awareness and educate all the people in the world of the Tuberculosis.

Tuberculosis is the second leading cause of death due to infectious diseases next to human immunodeficiency virus (HIV) with 1.2 to 1.5 million deaths annually. M. tuberculosis infections occur globally. The World Health Organization (WHO) estimates that one third of the world’s population becomes infected with M. tuberculosis every year. As reported by WHO in 2011, there were about 9 million newly reported cases of TB and 1.4 million deaths due to TB; TB linked HIV cases were reported to be about 430 000 (World Health Organization, 2012). TB coupled with HIV infection has become a leading cause of death for people suffering from HIV. HIV-positive patients are 20 to 40 times more prone to infection with this pathogen. Over the past ten years studies have revealed that five percent of the total TB cases are serious multi-drug resistant (MDR) infections. WHO reported an estimated 630 000 cases of MDR-TB in 2011, amongst a total of 12 million cases of TB worldwide (WHO, 2012).

Tuberculosis is among the fatal diseases that are spread through the air. It’s contagious, meaning that it spreads from one infected individual to another, and at times it spreads very fast. In addition to being contagious, the disease is an opportunist infection as it takes advantage of those with weak defense mechanism, and especially the ones with terminal diseases like HIV and AIDS. Tuberculosis is therefore among the major concerns for the World Health Organization due to its contagious nature (World Health Organization 1).

India, the second most populous country with over 1.31 billion people, has the highest burden of tuberculosis (TB) in the world, accounting for 20% of the global incidence of TB, and an even higher share of global incidence of multi–drug resistant (MDR) TB. With an estimated 2 million new cases of TB and 5, 00,000 TB-related deaths in India annually, those who got diagnosed with different forms of DR-TB were 35,385 cases but only 20,753 people started on multidrug-resistant TB (MDR-TB) treatment in 2013. The National Tuberculosis Program was launched in 1962, but suffered heavily continuing TB led mortality. Acknowledging this reality, a Revised National Tuberculosis Control Programme (RNTCP) was launched by the Government of India in 1997, however even today it does not comply with World Health Organization (WHO) recommendations.