Type 1 Diabetes Aetiology : Autoimmune Destruction Of The Beta Cells

Type 1 diabetes is also called insulin-dependent because the pancreas produce little to no insulin due to the destruction of beta cell in pancreas(Bardsley et al, 2004). Therefore, the insulin have to be injected manually for body to function normally. (Seewaldt et.al, 2000) states that in type 1 diabetes, the beta cell located in the islets of Langerhans have antigen that cause the immune system to produce antibodies and kill the insulin producing cells. The autoimmune response is thought to be caused by the autoreactive CD4 and CD8 effector cells that recognise islet self-antigens, as an outcome there is greater than 90% destruction on insulin producing cell BACH (1994). Similarly, (Nakayama et al,2005) and (Kent et al, 2005) supports that insulin in itself is a

The blood glucose level has very limited range for humans to survive and stay healthy. Generally, people are able to remove excess glucose rapidly from the body but this is not the case when they are diagnosed with diabetes and insulin resistant situations. The lack of insulin resistance can also lead to a decrease in glycogen synthesis and storage as it usually converts glucose to energy for cell’s use (Jensen & et al. 2011). When insulin is produced under insulin resistance, the cells are incapable of using them effectively which then leads to high blood sugar level as ketones and ketoacids are produced as an alternative energy source for the body. The rise of ketoacid causes the blood pH acidic and the patient may also be diagnosed with ketoacidosis (Newton & Raskin 2004). There would also be less intake of lipid and more of stored triglycerides as the lipids are effected by the insulin. As the glucose levels increase, the muscle glucose uptake will decrease while the liver glucose production and blood fatty acid concentration will also increase within the body (Lichtenstein & Schwab 2000). Excess glucose within the blood are converted to fat which can lead to Diabetic Dyslipidaemia and furthermore to obesity, hypertension and

DKA is presented with three major physiological disturbances which are hyperosmolality due to hyperglycemia, metabolic acidosis because of the buildup of ketoacids, and hypovalemia from osmotic diuresis. Diabetic ketoacidosis is caused by a profound deficiency of insulin, its most likely occur in people with type 1 diabetes, inadequate insulin dosage, poor self management, undiagnosed type 1 diabetes, illnesses and infections. In type 1

For unknown reasons, the body of a T1D attacks the insulin producing cells, called islets, that are formed in the pancreas and destroys them. This type of attack is known as an autoimmune disorder (Diabetes Research Institute Foundation [DRIF], n.d.). Insulin is the hormone that allows sugar to enter cells, and produce energy. The body now sees islet cells as foreign and eventually the pancreas yields little to no islet cells. Once there are no more islet cells to produce the insulin hormone the sugar levels in the blood become high, called hyperglycemia. This disturbance in homeostasis is not like type 2 diabetes (T2D), where the body becomes insulin resistant. In a T2D, the pancreas still produces islet cells and they are still

The disease of type two diabetes is largely due to the result of making consistently poor life style choices. It has been found that the disease of type two diabetes is largely caused by poor diet high in sugar, obesity, and also lack of exercise. It is possible that the disease of type two diabetes can also have a genetic factor, making the disease of type two diabetes hereditary. It has been found through research that there is a pre-condition that develops in people before the onset of the disease type two

Diabetes type 2 is a condition in which blood sugar levels are too high. After eating foods that contain carbohydrates, chemicals in the small intestine break down the carbohydrates into simple sugar molecules called glucose. The cell lining in the small intestine absorb the glucose, which then passes into the bloodstream. When the blood reaches the pancreas, beta cells inside the pancreas detect the rising glucose levels. To reduce the glucose level, beta cells release insulin into the bloodstream. As the blood circulates through the body, the insulin and glucose exit the bloodstream into tissue to reach the body’s cells. Most cells of the body have certain receptors on their surface that bind to the circulating insulin. Insulin acts like a key in a lick to open up the cell so that the circulating glucose can get inside the cell. The cell can use the glucose to produce the energy it needs to function properly. If a person has insulin resistance, insulin cannot unlock the cells to let glucose in because the locks, called receptors, are abnormal and/or missing. As a result, glucose is locked out of the cells. The amount of glucose builds up in the bloodstream in a condition called hyperglycemia. To compensate for hyperglycemia, the pancreas produces more and more insulin. Overworked beta cells try to keep with the demand, but gradually lose their ability to produce enough insulin.

Type 1 diabetes is a life long auto-immune condition where the immune system is activated to destroy the cells in the pancreas that produce insulin. Scientists are not sure what causes this auto-immune reaction (Vanstone et al. 2015). It can occur at any age, although it is most often diagnosed in children, adolescents or young adults. The immune system incorrectly sees the insulin-producing cells in the pancreas as foreign, therefore it destroys them. The role of these insulin-producing cells is to sense glucose in the blood, and in response produce the essential amount of insulin to regulate the blood sugar (Griffiths & Payne 2014 pp. 390-391). Insulin’s role is to get glucose from the bloodstream into the body’s cells. Without insulin,

The body regulates the blood glucose levels by producing insulin. Insulin is a chemical messenger essential for the entry of glucose into a cell. When the pancreas fails to produce insulin that is sufficient to use, the level of glucose in the blood will remain high. If to much insulin is produced, or given through medication, the level of glucose in the blood will remain low. In type 2 diabetes the cells become resistant to insulin and ignore its message to be absorbed into the cells, this is known as insulin resistance. Insulin deficit results in decreased transportation of glucose from cells in the body, hyperglycemia then arises causing to much glucose to be present in the bloodstream (Gould and Dyer, 2011: 550). The pancreas is located

Diabetic ketoacidosis is an event which occurs when there is not enough insulin in the body to utilize sufficient amount of glucose needed to provide cells with energy; body then starts to use fatty acids as a fuel, which are converted to ketones in the liver. In healthy people who do not have diabetes, ketone bodies are produced in normal quantities and then successfully used by tissues as energy supply. This state is known as dietary ketosis and it is completely normal and may even provide health benefits. But in those who have diabetes, ketones are produced in enormous quantities and aren't used in full by cells, so they start to build up in the blood. Acids 3-hydroxybutyric acid and acetoacetic acid are produced rapidly causing decrease in buffering capacity of the blood and eventually depleting buffering systems (Manninen, 2004).

Classic symptoms of diabetes usually presented with newly diagnosed diabetics are: hyperglycaemia, polyuria, polydipsia, polyphagia, fatigue, blurred vision, headaches, and unexplained weight loss. Ketone bodies are found in the urine, this abnormal finding occurs when fatty acid by-products (acetones) are excreted in the urine. The ketones are present from a lack of the insulin hormone used to metabolize fats and carbohydrates. Diabetic ketoacidosis (DKA) is a life-threatening complication which results from minimal useful insulin hormone in the body, hypoglycaemia, or insufficient food intake (American Diabetes Association, 2008).

Dehydration is induced by polyuria when the subject’s blood sugar is above 230mg/dL (hypoglycemic). The body’s loss of energy weakens the immune system and can cause easy limb loss if the skin is broken near the feat. Neuropathy (damage to the nerves) is due to the higher levels of sugar in the capillaries that feed the nerve endings. The sugar sticks to the sides of the capillaries and restricts the blood flow. The nerves in the eyes can also be damaged from the same process, leading to possible blindness. Polyuria can also damage the kidneys the same way alcohol can damage them. When the blood stream contains too much sugar or alcohol, the kidneys filter the excess out. When the kidneys are overused, the kidneys can shut down. The body needs glucose to function, and when the blood sugar drops below 20mg/dL, the brain makes the body go into a seizure. These seizures can be very dangerous and harmful to the body, leading to memory loss or personality changes; however, the body releases glucagon during the seizure causing the blood sugar to jump back to a tolerable

Diabetes is caused by reduced production of insulin, or by decreased ability to use insulin. Insulin is a hormone produced by the beta cells in the pancreas which allows the blood sugar cells to be able to use blood sugar. It is necessary for glucose to go from the blood to the inside of the body cells. Because of the poor insulin, glucose builds up in the bloodstream. The body is unable to use glucose for energy. When you are diagnosed with diabetes the doctor should try to stabilize the metabolism and eliminate the symptoms of high blood glucose because of the rapid onset of symptoms. The effects of diabetes are thirst, urination, vomiting, fatigue, and hunger which are the most common symptoms for. The extra sugar remains in the blood and

As we discuss acid and bases along with pH balance in blood a term that came to mind was Diabetic Ketoacidosis (DKA). This is a term that I have heard numerous times but didn’t not understand the meaning or cause. The term is commonly associated with diabetes but can also be associated with extreme exercise, low carbohydrate diets and eating disorders

Due to the lack of insulin patients with type I diabetes are unable to use glucose as their primary energy source, as a result their body switches to fat metabolism as its source of energy. As a result acidic ketones are produced as metabolic byproduct, this can be directly detected as a decrease in pH on ABG analysis. Patients with moderate to severe DKA have a blood pH ranging from 6.9-7.2, lowered bicarbonate levels and a carbon dioxide partial pressure in the rage of 15-20mmHg. The the cause of our patient her partial pressure of carbon dioxide was 15mmHg, bicarbonate was low and a blood pH of 7.14, these values suggest that the patient has metabolic acidosis and that the diagnosis of DKA is likely correct. While ABG analysis can be used to diagnose DKA several studies suggest that the ABG test results rarely effect a physicians diagnosis, treatment and management of the condition (3). In addition the same studies have shown that the pH venous of venous blood was precise enough to serve as a substitute to arterial pH analysis and is less painful for the patient

Counter regulatory hormones consist of cortisol, glucagon, growth hormone, and catecholamines. A rise in counter regulatory hormones cause insulin to not be utilize. This causes a rise in glucose, loss of fluids, loss of electrolytes, and ketosis (Kitabchi & Gosmanov, 2012). They worsen with the patient that has diabetic ketoacidosis because they increase glucose and ketone production in the liver when there is a severe decrease in insulin. This increases the ketone to even higher concentrations and the liver produces B-hydroxybutyrate. Ketones arise in the blood and may not