III. Need Screening
III.1 Disease State Fundamentals
A. Normal Physiology: Cholesterol is created in the liver for several body purposes such as creating and taking care of cellular membranes, also for hormone and vitamin construction. The liver constructs three- fourths of the total cholesterol in the body. The brain is also in need of cholesterol and produces some of the cholesterol it needs. However, the remaining amount of cholesterol required is obtained from the food eaten. The cholesterol is absorbed via the small intestine. There are two types of cholesterol; LDL and HDL. LDL or low density lipoprotein is more fatty is used for the development of cellular membranes, vitamins, and hormones. Normal LDL levels in the blood are 90 mg/dL. HDL or high density lipoprotein consist of more protein than LDL. HDL primary function is to collect extra cholesterol pieces and take it back to the liver for later use. When too much LDL has been released, the HDL is released by the liver and uptakes all extra LDL particles. This prevents any cholesterol from attaching to the artery wall.3:All
B. Pathophysiology:
Disease Function: While it is normal for cholesterol to enter the blood pathways due to food intake and liver release, however due to excess LDL cholesterol and lacking HDL cholesterol, the blood pathways can have a high concentration of cholesterol.1 High cholesterol levels cause a build up on the walls of the arteries which cause the artery pathway to narrow over time.1
In chapter 3 Dr. Moalem talks about how cholesterol rises too. Like when you consume alcohol, your body detoxifies it and then extracts calories from it. It's a difficult process that involves many different enzymes and a lot of organs, although most of the process takes place in the liver. First, an enzyme called alcohol dehydrogenase converts the alcohol into another chemical called acetaldehyde; another enzyme—cleverly called acetaldehyde dehydrogenase—converts the acetaldehyde into acetate. And a third enzyme converts
Good evening Mr. Brown your test results came in and we found out that your Triglycerides are 145 mg/dL, Cholesterol 210 mg/dL, HDL 33 mg/dL, and LDL 160 mg/dL. Normal triglycerides means there are less than 150 milligrams per deciliter (mg/dL) which you do have which is great. A desirable level of cholesterol would be Below 200 mg/dL, and borderline high would be 200-239 mg/dL so because your cholesterol level is 210 mg/dL you are at borderline high. Ideal LDL level for people at very high risk of heart disease would be below 70 and a high level would be 160-189 mg/dL your LDL level is 160 mg/dL therefore it’s high. The best HDL
The Framingham study and others that followed showed us that HDL-cholesterol is an independent cardiovascular risk factor and that the increase of HDL-cholesterol of only 10 mg/dL leads to a risk reduction of 2-3% (PubMed.gov, Nov. 2012). Higher levels of HDL cholesterol result in a risk of cardiovascular disease closer to the default risk. Cardiovascular disease risk increases then plateaus with greater ratios between total cholesterol and HDL cholesterol. Thus, higher levels of HDL cholesterol proportionate to levels of total cholesterol relate to lower cardiovascular disease risk (Lecture #3). Having a HDL-cholesterol of 60 mg/dL and above is the best place for a person to be. A bit lower, but considered a good HDL-cholesterol level standing is 40-49 mg/dL for men and 50-59 mg/dL for women. All three of us, me, my mother, and the case study Danny are in good standing regarding HDL-cholesterol levels, my mother with 55 mg/dL, me with 50 mg/dL, and Danny with 40
Cholesterol functions in the body as an energy source, and furnishes molecular components for the synthesis of various sex hormones.
In a study conducted in 1985 observing primates, it was determined that the major effect of dietary cholesterol is its LDL raising effects. High intakes of cholesterol increase the number of circulating LDL’s and it can also change its size and composition. [12] It was during this time period that the mechanisms by which SFA are thought to increase blood cholesterol concentrations came about. One mechanism for the increase in LDL cholesterol levels is the suppression of LDL receptor activity. Studies in tissue cultures have shown that increasing the cholesterol content of a cell will down-regulate synthesis of LDL receptors. [13] This will lead to an increase in concentration of blood cholesterol. Another cause for an increase in blood cholesterol concentration through intake of dietary SFA is the composition of the newly secreted lipoproteins. With a high saturated fat intake, the LDL’s become rich in cholesterol esters, leaving the triglycerides in the blood. [14] The use of non-human primates in
High cholesterol is one of the most common diseases that occur in today's society. According to Centers for Disease Control and Prevention, 71 million American adults have high LDL "bad" cholesterol. When cholesterol levels are normal, they normally do not harm the body since cholesterol can be beneficial to the body. However, if excess amounts of cholesterol are in the body, it can become a threat. "Cholesterol is a waxy substance that plays an important role in building cell membranes and sex hormones" (Overview). The certain types of food you consume on a daily basis may affect the cholesterol levels in your blood. There are two types of cholesterol, which is your HDL (high density lipoprotein), "good", cholesterol, and your LDL (low density lipoprotein), which are the "bad" cholesterol. It is critical that an individual maintains his or her cholesterol levels because he or she can increase their risk of cardiovascular disease. LDLs are known to carry cholesterol into your arteries and clog them, which can cause strokes and heart attacks. On the other hand, HDL, help eliminate cholesterol from the arterial vessels and transport it to the liver, which is then defecated with body waste. According to Sroda, an individual's total cholesterol should be less than 200, LDL levels should be less than 130,
Our body naturally produces cholesterol through the liver, we can also obtain cholesterol from consumed products. We need small amounts of cholesterol to produce hormones, bile, and vitamin D. Cholesterol doesn’t dissolve in the bloodstream once it is inside the body. It needs to be carried by two types of lipoproteins called low density lipoproteins(LDL) and high density lipoproteins(HDL). The more cholesterol we consume, the more LDL and HDL we produce. HDL is
High cholesterol is a dangerous disease that can lead to many life-threatening ailments, and can be lowered by eating healthy, while maintaining a balanced diet of leveled cholesterol. Cholesterol, the sleek-fat like substance that roams in the blood of a body. It is vital to life, but when there is too much intake of cholesterol, it can cause the body to malfunction and cause problems. There are two types of cholesterol HDL and LDL, which varies in the amount of protein and cholesterol it holds Too much cholesterol in a body is dangerous, and surprisingly, has no symptoms. The two main types of cholesterol are HDL and LDL, HDL helps reduce the chances of chronic heart disease, whereas LDL is the main reason for plaque build-up in artery
A routine cholesterol screening involves a simple blood test. An LDL number of 190 mg/dL is considered high, but an HDL level below 40 mg/dL is too low and is a risk for heart disease. The levels of both HDL and LDL are added together for a total cholesterol number. The risk breakdown for the levels are;
Cholesterol is a lipid that helps manufacture vitamin D on the surface of the skin, produces hormones, maintains cell membranes, and possibly helps cell connections in the brain.3 Based on what is known about calcium transporting throughout the body we can infer that cholesterol also has a similar process. When there is an imbalance of cholesterol homeostasis we can have high density lipoprotein (HDL) which is known as good cholesterol, or low-density lipoproteins (LDL) which is known as bad cholesterol. Lipoproteins differ in size, shape, composition, function, and contribute to vascular
Use the equation of HDL + LDL + 20% of the Triglyceride level to calculate your total cholesterol level. This number should be less than 180 mg/dL for healthy total cholesterol. Your “bad cholesterol” or low-density-lipoprotein or commonly known as LDL levels should be on the low side. Levels of less than 100 mg/dL are the best levels. 100- 129 mg/mL are close to ideal. Borderline high would be levels of 130-159 mg/mL, high risk levels are 160-189 mg/dL and the worse, highest risk levels would be over 190 mg/dL. (6) The American Heart Association or AHA guidelines snow state that LDL levels are no longer a guideline for preventing heart attacks and no longer need to be taken into account. The level is strictly used to calculate your total cholesterol level. The AHA guidelines also state that people taking statins no longer need to have their LDL levels under a certain level. In “good” Cholesterol or High-density-lipoprotein also known as HDL we look at higher level as being healthier. For Men their healthy levels need to be over 40 mg/dL and
When your doctor talks to you about cholesterol, you might heart certain terms related to your cholesterol levels. Cholesterol is found in animal foods, such as chicken, meat, milk, eggs and cheese. Try to keep your total blood cholesterol under 200 mg/dL. LDL is known as the “bad” cholesterol, as heightened levels can damage your arteries and lead to a heart attack or stroke. Normally, LDL levels should be less than 130 mg/dL. However, a doctor might recommend levels as low as 70 for people with diabetes and/or heart disease.. HDL is referred to as “good cholesterol,” because it helps to keep the arteries open to help reduce the risk of heart disease. You can use an HDL testing kit at home to determine if your level are greater than 50 for men and more than 40 for women. Triglycerides are also a negative element, as they produce LDL and prevent HDL from removing it from your blood. Your triglycerides should be below 200 mg/dL. Talk to your doctor about ways to lower your cholesterol, such as diet, exercise and medication, such as
Hi Mr. Brown how are you today? On today`s visit we will be going over your cholesterol panel we receive back all your test results for your cholesterol levels. Your triglycerides levels are at 145 milligrams per deciliter. Your levels are under the normal range of 145 milligrams per deciliter, which is good because your levels are under the high borderline which is between 150 to 199 milligrams per deciliter. This is great that your levels are normal Mr. Brown because Triglycerides are a type of fat known as lipid that’s found in your blood. When you eat food, your body converts any calories it doesn 't need to use right away into triglycerides. The triglycerides are stored in your fat cells. After the hormones are released into triglycerides for energy between meals. If you eat more calories than you burn, then the calories like fats and carbohydrates, can cause you to have a high triglycerides result. So basically, Triglycerides help in the digesting process and breaking down the fats in the food we eat. The results for your cholesterol level are 210 milligrams per deciliter which is borderline high considering, the normal range for cholesterol levels are less than 180 milligrams per deciliter. Since your body has to have cholesterol to make Vitamin D, your hormones, and it also helps with the digestion of the meals you eat. See cholesterol is like a wax, fat like substance that is found in the cells in our bodies.
The good form of this sterol in the body is your HDL, because it picks up all the bad form in your body and store it in the liver to be converted into the bile then exits out.
Tutt: Nice that you should mentioned that Mr. Brown. Cholesterol is found in your blood. Have you ever gone to the store and read the back of the label that stated “low in cholesterol”? Well that’s the food found in meat, fish, eggs and low fat milk, but be careful Mr. Brown you can have too much cholesterol. The cholesterol can stick to your blood vessels and stay there causing the pipes to become narrow this can clog the blood vessels and keep the blood from moving freely and we do not want that to happened. If the clogging gets worse it can lead to a heart attack or even a stroke. There are two types of cholesterol HDL and LDL. We will go over both and I will provide your results for each. HDL (high-density lipoprotein) cholesterol, it helps carry cholesterol back to the liver. On the other hand, LDL (low-density lipoprotein) can clog the blood vessels due to it moves the cholesterol away from the bloodstream which causes it to stick to the blood