Understanding Human Immunodeficiency Virus-1 from an Epidemiological, Animal Model, Cognitive and Neurological Perspective ***Look for MORAN, L 2014 Paper*** Human immunodeficiency virus type I (HIV-1) is characterized by secondary infections, cognitive and behavioral impairments, and neurological impairments (Reid et al. 2001; Vigorito et al. 2007; Lashomb et al. 2009; Moran et al. 2014; Bertrand et al. 2014; Roscoe et al. 2014). In 1996, the development of combination antiretroviral therapy (CART), which combines three or more antiretroviral drugs in combination, improved life expectancy for those with HIV-1 (CDC, 2014). However, despite the advent of CART, the total incidence of HIV-1 associated neurocognitive impairment has remained the same (Moran et al. 2012). HIV-1 can be characterized by studies conducted in epidemiology, the creation of the HIV-1 transgenic (Tg) rat model, studies of spatial learning, and dendritic alterations in HIV-1 rats. Many studies have focused on understanding the prevalence of HIV-1 among childbearing women, and the number of children living with HIV-1 (Gwinn, et al. 1991; Davis et al. 1995; Chiriboga et al. 2005). In 1994, vertically acquired transmission of HIV-1 from mother to infant accounted for 92% of all new cases of AIDS in the United States (Davis et al. 1995). Davis et al. (1995) estimated HIV prevalence between 1978 and 1993 by using data from the national HIV survey of childbearing women, the national AIDS case surveillance
As we read chapter two, we saw a comparison between the book and the poem we had read earlier. The poem first talked about how Chicago does not have a good justice system. It also described the women that lived there as prostitutes and how their children were terrified of the city. Then, the poem revealed how the city of Chicago was dark and smoke filled. The city represented darkness, but the people of the town were still proud of it. Even though it was a dark town, it still thrived in jobs and even in the railroad system. The pride of Chicago was something many experienced.
Prior to World War I, posters were already a mature advertising tool. They were also valued and collected as art. Thus, propaganda posters could depend on viewers who were familiar with its visual elements (using a traditional tool to articulate something new).
Halloween is an international holiday that is celebrated every year on the 31st of October. Halloween is a holiday that consists of a history of traditions that have been evolved to fit more modern times. Halloween is considered an ancient tradition that was once religious. Halloween has a rich history and has influenced thousands of cultures throughout the 2,000 years that the holiday has been in practice.
For visual purposes, I have included graphs to show the correlation between the prevalence of HIV based off income and U.S. impoverished areas. As the picture has depicted, those who are in a higher income bracket are at a substantial advantage. Those who are impoverished have the highest prevalence of HIV in their communities.
Such impairment is clinically manifested by a decrease in the cognitive abilities and motor skills of the patient. Although, HIV invades the nervous system very early, the manifestations appear late in the development of the individual, and it is usually associated with severe immunosuppression (Shors, 2011).
The human immunodeficiency virus (HIV) is an organism known as a retrovirus. Like any virus, HIV must use the cells of another organism – its host – to survive and reproduce. HIV is adapted to using the cells of the human immune system. HIV has its origin in the transmission of simian immunodeficiency viruses (SIVs) from non-human primates, mainly chimpanzees, to humans. Such
HIV, also known as the human immunodeficiency virus, can have diminishing effects on the body’s immune system. Unlike other viruses, such as the flu, the body cannot get rid of HIV. This virus attacks T-cells (T-cells play a huge role in cell immunity), and replicates itself among the attacked T-cells. When too many of the cells have been attacked, and the body can longer fight infection, the HIV infection can then transform into AIDS. (Acquired immune deficiency syndrome)
HIV is one of the most feared diseases around the globe since its “discovery” in 1981. HIV stands for human immunodeficiency virus and is caused by Lentivirus, which is a subgroup of Retroviridae (Douek et al. 2009). HIV is one of the more dangerous diseases known because there is currently no known cure and will infect roughly 50,000 people in the United States alone each year (CDC 2016). HIV is a terrible disease that has taken the world by storm. While originally only known as a homosexual disease, that false perception has been shattered as the disease continued to spread. The origin of HIV is not entirely known, though there is strong evidence to support the idea that it originated in a chimpanzee in West Africa. They
Human immunodeficiency virus is most commonly known as HIV.18 It debilitates a person’s immune system by destroying important cells that fight disease and infection. It can spread through certain body fluids that assault the body’s immune system, specifically the CD4 cells often called T cells.1 These essential cells help the immune system fight off infections.1 Untreated, HIV reduces the number of CD4 cells in the body.1 The damage brought on by HIV to the immune system makes it extremely difficult for the body to fight off infections and diseases. Eager infections or cancers take advantage of a very weak immune system and signal that the person has AIDS. No effective cure exists for HIV. Scientists identified a type of chimpanzee in
The human immunodeficiency virus (HIV) that causes AIDS (auto immunodeficiency syndrome – the final stage of HIV) can be classified as one of the most devastating epidemics in United States history (Centers for Disease Control and Prevention [CDC], 2015). Although still an alarming concern in public health, due to prevention strategies and medical advances, the disease is less fatal and is treated as a chronic disease (instead of a death sentence, as in the past). There are currently 1.2 million people living in the US with HIV (CDC, 2015). The highest rates transmitted through sexual intercourse or injection drug use through the exchange of bodily fluids (CDC, 2015). It is estimated that 25% of those living with HIV are women, and only
At the end of 2011, an estimated 1.2 million people aged 13 and older were living with the human immunodeficiency virus (HIV) in the United States, and the Centers for Disease Control and Prevention (CDC) estimated that approximately 50,000 people are newly infected with HIV each year (CDC, 2013). Fortunately, after more than 30 years of research on HIV, much progress has been made in fighting this disease. Antiretroviral therapy (ART) transformed what was once a death sentence into a manageable disease for individuals with drug-susceptible viral strains, who have access to antiretroviral drugs, and are compliant with their prescribed therapy. ART not only prolongs life, but also dramatically reduces the rate of HIV transmission (Deeks et al., 2012). Unfortunately, substantial challenges exist to maintain access to and funding for lifelong ART (Dolin et al., 2009; HRSA, 2012; Lewin, 2013), standard therapies do not fully restore health or a normal immune system in HIV-infected individuals, and patients still experience comorbidities, such as increased cardiovascular diseases, bone disorders, and cognitive impairment (Deeks et al., 2012; Hsue et al., 2012; Phillips et al., 2008). It is possible that these HIV-associated complications are due to the toxic effects of treatment or the consequences of persistent inflammation and immune dysfunction (Katlama et al., 2013). Therefore, the International AIDS Society (IAS) convened a team of more than 40 scientists
According to International AIDS Vaccine Initiative (IAVI) (2016) in 1983, scientists and researchers discovered that human immunodeficiency virus (HIV) directly causes the immunodeficiency syndrome (AIDS). Unfortunately, over 40 million of people worldwide have died due to AIDS and other complications relating to AIDS (IAVI, 2016). HIV and AIDS have spread over the world in drastic speed and caused one of the most destructive pandemics ever recorded throughout history. Despite the advancements and availability, yet very expensive antiretroviral treatments available, fifteen million of people are currently living with HIV (IAVI, 2016). Fortunately, the total yearly count of AIDS-related deaths and number of new HIV infections has declined in the last decade (IAVI, 2016). However, much more technological, medicinal and research advancements need to be developed in order to address this destructive virus.
This paper explores the human immunodeficiency virus (HIV) as well as the simian immunodeficiency virus (SIV). The virus has infected two million adults and children by the year 2005 already. The virus continues to race around the world, and new HIV infections are at 50,000 per year (Martine Peeters, Matthieu Jung, Ahidjo Ayouba) (2013). The final outcome of the HIV infection is Acquired Immune Deficiency Syndrome (AIDS). There are many treatments that have developed to help the large number of people infected (Demmer, 2002). HIV greatly spread throughout Africa while originating with African chimpanzees. There are many different theories as to what started the HIV outbreaks, but all theories come to the same conclusion that there
Human Immunodeficiency Virus (HIV) is a virus that infects the cells of human immune system, causing destruction and impairing the cellular functions. Progressive deterioration of the immune system at cellular level causes associated infection to undermine the immune system putting the patient at risk of opportunistic infections. Acquired Immunodeficiency Syndrome (AIDS) is the most advanced stage of HIV. AIDS is caused when HIV related cancers hit the immune system by 20 or more opportunistic infections. According to the World Health Organization (WHO) by the end of 2016, 36.7 million people (30.8-42.9 million) were living with HIV globally. Approximately 0.8% (0.7%-0.9%) adults between the age group of 18-45 were living with HIV and 76%
Human immunodeficiency virus (HIV) is the causative agent responsible for the most common sexually transmitted disease in the world known as acquired immunodeficiency syndrome (AIDS) (Handsfield, 2011). HIV/AIDS has been existent for over three decades, and the occurrence of AIDS was first clinically identified in 1981 among five men in Los Angeles, California exhibiting symptoms of pneumocystis carinii pneumonia (PCP) and whom were also sexually active with other men (De Cock, Jaffe, & Curran, 2012). The causative agent of AIDS was later identified to be HIV and it continues to affect several individuals worldwide. It is estimated that 35.3 million people are living with HIV globally and is deemed a global burden (Maartens, Celum, & Lewin, 2014)(De Cock et al., 2012).