Unit 2 Assignment 1 Cellular Structures and Pathogenicity
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Cellular Structures and Pathogenicity
Jennifer L. Wethington
ITT Technical Institute
Unit 2 Assignment 1 “Bacterial illness is a result of complex interactions between bacteria and the host. During evolution, humans developed many ways to protect themselves against bacterial pathogens. On the other hand, bacteria have developed strategies to evade, subvert or circumvent these defenses” (Sousa, 2003) “One of the most important characteristics of bacterial pathogenicity is the various strategies developed by prokaryotic organisms to use host molecules for their own benefit” (Sousa, 2003). “To accomplish this, bacteria have evolved elaborate control mechanisms to turn genes on and off, varying the transcriptional activator or…show more content… “In the initial phase of infection, environmental strains of P. aeruginosa from any aqueous setting are inadvertently inhaled or otherwise delivered to the upper respiratory tract” (Feldman, et al., 1998). “It is at this stage where the expression of functional flagella is critical, providing chemotaxis toward desirable substrates, such as mucin, and the motility essential for widespread dissemination” (Feldman, et al., 1998). “In the normal host, the presence of defenses and additional antimicrobial peptides, the affinity of flagella components for mucin glycopeptides, and the process of mucociliary clearance are likely to eradicate such transiently inhaled organisms from the respiratory tract before any epithelial immune response is elicited” (Feldman, et al., 1998).
“While motility is commonplace among the prokaryotes, it is important to note the variety of structures responsible for motility. These structures vary depending not only on the organism in question, but also on the particular environment” (Bardy, Ng, & Jarrell, 2003). “Study of the bacterial flagellum has provided insights into many aspects of prokaryotic cellular activities including genetics and regulation, physiology, environmental sensing, protein secretion and assembly of complex structures” (Bardy, Ng, & Jarrell, 2003). “Continued study of all prokaryotic motility structures will provide knowledge that is likely to reach far beyond the topic of motility and pathogenicity” (Bardy, Ng,