Use Of Isosorbide Dinitrate And Commiton With Other Ethnic Groups

787 WordsNov 15, 20174 Pages
Clinical evidence: Comparison with Other Ethnic Groups: Isosorbide dinitrate and hydralazine are frequently used together in the treatment of heart failure particularly with reduced ejection fraction. They complement each other as isosorbide dinitrate is a nitric oxide donor and hydralazine is an antioxidant that prevents the destruction of nitric oxide. Studies have been done to investigate the use of isosorbide dinitrate and hydralazine together among the general population as well as specifically in the African American population. According to the article Use of Hydralazine-Isosorbide Dinitrate Combination in African American and Other Race/Ethnic Group Patients With Heart Failure and Reduced Left Ventricular Ejection…show more content…
Comparison with Other Treatments: There are a plethora of treatments available for patients with heart failure including but not limited to diuretics, ACE inhibitors, angiotensin receptor blockers, and oral nitrates. The Vasodilator heart failure (V-HEFT) studies show that enalapril has less cumulative mortality among study participants when compared to patients taking a combination of isosorbide dinitrate and hydralazine. (MGMT) This is not to say that the combination of isosorbide dinitrate and hydralazine is not efficacious because when compared to placebo, mortality rates improved with the combination treatment. Enalapril, which is a part of the class of drugs called ACE inhibitors, is superior to the combination treatment mentioned above but is not an option for many patients. There is a subgroup in the general population that cannot tolerate ACE inhibitors or ARBs due to their side effects. In this case, the combination of isosorbide dinitrate and hydralazine is a superior treatment for these patients. (MGMT) Overall, the combination treatment is inferior to other heart failure treatments but it still has its own place in heart failure treatment guidelines. Key Observations: Some key observations that we found throughout these clinical reports are that patients are offered numerous treatment options when diagnosed with heart failure. However, these treatment options are often restricted due to comorbid disorders/diseased the patients

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