Use of Ramipril and Carvedilol Combination Therapy in Heart Failure

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Assignment: Treatment of Heart Failure: The severity of HF is determined by The New York Carvedilol and Ramipril Heart Association classification (NYHA), which is Keywords: Heart failure, beta-blockers, carvedilol, summarized in the table 15. angiotensin-converting enzyme inhibitors, ramipril. INTRODUCTION Heart failure (HF) is the disease of the elderly. Over 70% of the patients are older than 65 years. The risk of having the condition rises with age. HF can be defined as a clinical syndrome. The ability of the heart to pump blood is impaired and it can no longer meet the body’s metabolic requirements Table 1. New York Heart Association Classification of Heart Failure. Remme WJ, Swedberg K. Guidelines for the diagnosis and…show more content…
It was al., 2006) suggests that the drug blocks ATP- proven that these therapies significantly reduce the sensitive (KATP) and G-protein-activated (KG) risk of mortality and improve the symptoms. potassium However, by hyperinsulinemia and hypoglycemia. It is believed implementing multi drug therapy. ACE inhibitors that the KG channel is opened by G protein in can cause hypotension, cough, and worsen the renal response to stimulation of G-protein-coupled function. Cough can cause patient noncompliance, muscarinic acetylcholine receptors in atria and sino- which in turn may result in the need of different atrial node cells. Therefore, the inhibition of this drug therapy. Beta-blockers can cause bradycardia, channel would result in anti-cholinergic effects in hypotension, fatigue and fluid retention. Also, in the heart12. Study patients there with and Australian-New are risks diabetes, associated beta-blockers ion channels. This results in could potentially mask the symptoms of hypoglycemia7. Pharmacodynamics Carvedilol is a racemic mixture of R and S Carvedilol enantiomers. Both enantiomers show α1 receptor Carvedilol is a non-selective beta-blocker (ß1 and inhibition. However, only S enantiomer inhibits ß ß2) has adrenoreceptors. It competitively blocks both ß1 and vasodilatation and antioxidant effects. Previously it ß2 receptors. The drug reduces high blood pressure was be mainly due to the α1 and ß blockage. The

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