Using Quorum Sensing Mechanism And The Inhibition Of Qs

810 Words May 15th, 2015 4 Pages
Abstract:
Several antibiotic resistant bacterial strains exist due to the inappropriate usage of antibiotics themselves as a result of this an alternative treatment is required. Quorum sensing (QS) is a process of cell-cell communication, which controls the expression of virulence factors by pathogenic bacteria. There is evidence to suggest that the inhibition of QS in bacteria would reduce or inhibit virulence factors being produced and could also prevent biofilm formation. This review focuses on quorum sensing mechanism and the inhibition of QS in gram-negative bacteria. QS inhibition has been explored as a novel anti-pathogenic therapy to control bacterial infections with promising results in several previous studies.

Introduction

Excessive and indiscriminate usage of antibiotics has led to the emergence of multiple drug resistant (MDR) bacterial strains. The need for alternative approaches to combat these MDR strains stem from the fact that 16 million people die annually due to infectious diseases caused by them (Bjarnsholt. et al., 2005 and Rasmussen. et al., 2005). It has been repeatedly observed that bacteria within these specialised structures are around 1000 times more resistant to antibiotics than their free-living counterparts (Martinez and Baquero, 2002). Bacterial behaviour within biofilms is regulated by a process named quorum sensing (QS), where bacteria release chemical signals and express virulence genes in a cell density dependent manner (Ganin et al.…
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