Using Radiotherapy On Hepatoblastoma ( Hb ) Is The Most Common Malignant Embryonal Liver Tumor

Cancer is defined as the abnormal, uncontrolled division of cells in the body. This uncontrollable growth causes a growth or tumour on the body. The tumours that are formed can either be benign or malignant. Malignant tumours can attack other cells and destroy them. Cancer has been around for ages and millions of people have died from cancer. There are many types of cancer and there are different reasons why people get cancer. Luckily, there are many treatments in place to help people who have cancer. Some popular options for treating cancer would be surgically removing the tumour or growth, or undergoing radiation therapy or chemotherapy. These treatments are commonly used amongst patients who have cancer. Alternatively there is another treatment that could be used to cure cancer, Proton Therapy. Proton Therapy works by directing a strong dose of radiation to the cancerous tumour (Advanced Particle Therapy, n.d.). In this essay, the advantages and disadvantages of Proton Therapy will be discussed in

From surgery to radium exposure to such extremes as radiation therapy, as doctors’ knowledge of the varying types of cancer, and the expansion of medical research regarding cancer has changed, so has the preferred method of treatment. Doctors and researchers dedicated to studying cancer have led to a greater understanding of cancer development; consequently the development of treatments and cures that are more effective, less harmful, have fewer side effects, and in some cases serve to prevent the spread of cancer.

Cancer is an incurable and unpredictable disease that, if left untreated, will likely result in death for the men, women, and children who must fight it. Sadly, approximately 36% of people will develop cancer during their lifetime, and of that percentage, fewer than 15% will survive, according to the National Cancer Institute. Along with surgery and chemotherapy, radiation is one of the few known methods for treating cancer, but it does not come without harmful side effects. While radiation therapy is currently a proven method for treating cancer, dangers to patients often outweigh its benefits, therefore a safer method for effectively treating and ultimately curing cancer.

Usually, radiation therapy is treated by neoadjuvant, adjuvant or definitive treatment with systemic therapy. Around 20% to 80 % of the patients with cancer received radiation therapy through the way of their treatment (de Gonzalez et al., 2011). In this treatment the radiation is usually given along with chemotherapy, which is recognized as chemoradiation or chemoradiotherapy. The Duke University conducts investigational study of neoadjuvant radiation therapy in 96 resectable patients. Everyday patients who received 50.4 Gy dose of radiotherapy are combined with 5-FU-based chemotherapy. After this patients were then surgically findout if there was no evidence of metastatic disease and less mortality. Overall survival (OS) and median survival was (28%:23 months) respectively (Spitz et al., 1997; White and Tyler, 2004). In 1980’s The Gastro-intestinal Tumor Study Group (GITSG) conducted randomized study in purpose of adjuvant chemoradiotherapy in resected pancreatic cancer. After R0 resection 49 patients were treated with chemorediotherapy for evaluation of adjuvant

Cancer is a genetic, heritable disease in which abnormal cells divide rapidly destroying normal body cells, often being fatal. Cancer can occur in any body tissue; skin, organs, and parts of the reproductive system (Duda). There are various activities linked to different types of cancer, such as smoking, too much sun exposure, gene mutations, carcinogens, and viruses. A major cause of cancer, dating all the way back to the 1950’s, is radiation. Atomic testing ordered by the U.S. Government has been suspected to be the cause of many deaths linked to radiation-related diseases (Williams 149).

Doctors had been using radiation to destroy cancerous cells since the unfolding of X-rays and radium in the 1890s, but both techniques had their own issues. X-ray machines were complicated to make use of, and radium implanted near tumors. In addition, X-rays weren’t strong enough to be entirely effective, and as for both of them, they were quite expensive.

Liver cancers are malignant tumours that grow inside or on the surface of the liver. They form from the liver or structures inside the liver, for example, blood

I can draw from these results that as the chemotherapeutic drug concentration is increased the cell viability decreases. In HEPG2 the viability at the control was 100% but when the drug was added at concentration of 40µm the cell viability decreased to 2.62%. From these examples we can deduce that the chemotherapeutic drug added is successful in its use and that it is targeting the cancerous cells. The drug damages the genes present inside the cell line

Liver cancer is in the top ten for most alarming cancers. It is placed in the abdominal cavity. Also it is placed to the right of the stomach under the diaphragm. A average adult liver receives about two quarts of blood every minute and weighs around three pounds. The biggest glandular organ in the body is the liver and it keeps damaging substances and toxins out of the body. The liver is an critical organ in our body because it stocks vitamins, iron, and sugar glucose. It produces bile which is a substance to digest fats and it destroys old RBC. Also the liver detoxifies the blood to rid it of damaging substances such as drugs and alcohol and breaks down hemoglobin as well as insulin and other hormones. Lastly the liver alters ammonia to urea,

Radiation therapy is the ionization of atoms in tissues resulting in formation of highly reactive radicals in a well-defined, restricted volume (1). In other words, ionizing radiations are used to eradicate tumors and at the same time preserve structure and function of normal tissue. A limitation is prevented from being a problem. If bone marrow or neuronal cells are destroyed or injured, they do not regenerate. However, with radiation therapy, these cells are often saved from injury or destruction, unless the tumor is infecting bone marrow or neuronal cells. Today, radiation therapy is the most popular type of cancer therapy in use. It is used to treat one-half to two-thirds of all cancers, which translates to more than ten percent of the population

Cancer is very uncommon in children but, sadly, it does happen. Cancer does not discriminate. It can affect both boys and girls, those of any race or social class, and it can be diagnosed in babies as well as young adults. The most common types of childhood cancers are leukemia, lymphoma, and brain cancer. Most cancers in children result from mutations in the genes of growing cells, which is much different than cancer in adults where it is primarily attributed to lifestyle or environmental factors. Because the cause of childhood cancer is unknown, there is no way of preventing it. A diagnosis is often made during a child’s regular checkup, when the doctor detects something abnormal. Some of the first symptoms include fever, swollen glands,

Radiation therapy is the use of high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and shrink tumors (National Cancer Institute, 2016). One of the main purposes of radiation is to preserve the normal cells while killing the cancer cells. To fully understand the importance of radiation therapy it is imperative to understand its discovery. The discovery of radioactivity is attributed to Henri Becquerel in Paris. His discovery was purely accidental, as most discoveries are, while attempting an experiment that utilized the sun, uranium, and photographic plates. On 26-27 February 1896, Henri Becquerel took the uranium and photographic plates wrapped in black paper to initiate his experiment by placing them in the path of sun light, but to his misfortune it was overcast both days. Thinking that his experiment was a failure, Becquerel decided to develop the photographic plates and found that uranium did not need the sun’s rays to emit radiation due to its own radioactive properties, thus discovering radioactivity. The actual term “radioactivity” was coined by Marie Curie, a Polish born physicist, who along with her husband had been studying the phenomenon that was discovered by Becquerel (Lawrence Berkely National Lab, 2000).

Lakhole also manages patients whom are facing or have undergone liver transplant. Few hospitals offer pediatric transplantation operations. As a result, pediatric hepatologists with experience in the treatment of pediatric liver transplant patients are rare. Dr Lakhole’s commitment to this field is evident in the academic articles written by her in this field. One such article is titled “Review of Pediatric transplantation” for which she reviewed >60 peer review publications. This will be published in the reputed journal Expert Review Gastroenterology and Hepatology.

In 2007, it is predicted that almost 1.5 million people will be diagnosed with cancer in the United States (Pickle et al., 2007). More than half of these cancer patients will undergo the use of radiation as a means for treating cancer at some point during the course of their disease (Perez and Brady, 1998). Cancer, a disease caused by an uncontrollable growth of abnormal cells, affects millions of people around the world. Radiotherapy is one of the well known various methods used to treat cancer, where high powered rays are aimed directly at the tumor from the outside of the body as external radiation or an instrument is surgically placed inside the body producing a result of internal radiation. Radiation is delivered to the cancerous regions of the body to damage and destroy the cells in that area, terminating the rapid growth and division of the cells. Radiation therapy has been used by medicine as a treatment for cancer from the beginning of the twentieth century, with its earliest beginnings coming from the discovery of x-rays in 1895 by Wilhelm Röntgen. With the advancements in physics and computer programming, radiation had greatly evolved towards the end of the twentieth century and made the radiation treatment more effective. Radiation therapy is a curative treatment approach for cancer because it is successful in killing cancerous tumor cells and stop them from regenerating.

Tumors are one of the most feared diseases of our time. Many people upon hearing the word “tumor” immediately resonate to the conclusion of it being cancer, which is not necessarily true. Tumors fall into to two main types, benign and malignant. Although they are considerably different in tissue invasion, their nature that makes them distinct and symptoms, they are also quite similar in the way they recur in the same location, growth size and their health risks.