Using The Method Of S2

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Method The method of S2 was to conduct a nested-case-control study. Utilizing a national database of civil registration numbers, through which all databases were linked and a university prescription database. The inclusion criteria were to have a prescription history of Met > or = two years before the diagnosis of PCa (index date). For every case in the study 10 controls were selected and those controls were born the same year, alive, and resided in the same area < two years before the index date of the case. Results S2 identified 12,226 cases of PCa and selected 10 controls per case for a total of 12,260 controls. Met users were found to have a reduced risk of PCa when compared to never users of Met (adjusted OR [aOR]: 0.84; 95% CI,…show more content…
The study was publishes in 2015. This study determined the optimum prostate-specific antigen (PSA) value coupled with free PSA% (FPSA%) to reduce the number of unnecessary biopsies performed on benign prostate disease while identifying significant tumors of prostate cancer (PCa). The study involved 2,225 Caucasian patients who experienced biopsies between the years of 1995 and 2012 and were in the Biobank. The patients were stratified into four age groups: < or = 49 years, 50-60 years, 60-69 years, and > or = 70 years. To determine the new PSA cutoff values, scenarios were simulated with sensitivity and specificity calculated for all PSA cutoff values from 1.25 ng/ml to 6 ng/ml in increments of 0.5 ng/ml and FPSA% values of 15%, 18%, and 20% were compared and contrasted for all groups. Sensitivity was determined to be 88% in all groups, this value was utilized as the lower limit for the new cutoff values and among that group of > or = 88% those with the highest specificity and sensitivity were utilized as the new PSA cutoff values. Statistical analysis was calculated for the new cutoffs, including a 95% confidence interval. The receiver operating characteristic curves with stratified FPSA% values of < or = 18% vs. > 18% and < or = 21% vs. 21% were noted. The proposed new cutoffs for PSA, the FPSA% and the reduced number of biopsies
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