Von Willebrand Disease

According to the National Hemophilia Foundation (n.d.), von Willebrand disease (VWD) is a genetic disorder caused by missing or defective von Willebrand factor (VWF), a clotting protein. VWF binds factor VIII, a key clotting protein, and platelets in blood vessel walls, which help form a platelet plug during the clotting process. The condition is named after Finnish physician Erik von Willebrand, who first described it in the 1920s (National Hemophilia Foundation, n.d.). The seriousness of the bleeding varied between family

Mutations lead to a genetic deficiency in clotting factor VIII, causing increased bleeding and affects males a majority of the time. HA can occur in homozygous females. 5-10% of patients with HA have dysfunctional proteins (factor VII) and 90% to 95% of HA cases are characterized by a quantitative deficiency pf factor VII. Patients usually experience bleeding episodes: the most serious bleeding sites include, joints, muscles, digestive tract, and brain. 30% of cases are caused by new mutations. Medications are prescribed to prevent bleeding episodes and for more severe cases blood coagulate and blood plasma treatments are

Hemophilia, once called the royal disease is a problem with the clotting of blood. When a cut or bruise occurs it can bleed causing problems with people who suffer from hemophilia. Patients with hemophilia will continually bleed longer than a normal individual. This bleeding can lead to harmful levels of blood loss to internal bleeding. Hemophilia is very rare occurring once every five thousand people. Rare, however it is the most common x linked trait. When an injury occurs, blood cells called platelets plug the wound. Then fibrins seal it up. Hemophilia splits into two groups hemophilia A and hemophilia B. People who have hemophilia A have low levels of blood clotting factor 8. Hemophilia B patients have low levels of blood clotting factor

Von Willebrand Disorder, abbreviated as VWD, is the most common inherited bleeding disorder. Erik von Willebrand, a Finnish scientist, first discovered it in the 1920s. Carried on the twelfth chromosome, von Willebrand causes excessive bleeding (National Hemophilia). Patients with VWD form blood clots slower, resulting in prolonged bleeding. As a lifelong condition without a cure, it can come with serious health hazards. Roughly one percent of the U.S. population, or one out of one hundred to a thousand people, have this ailment. However, other bleeding disorders, such as hemophilia, occur mainly in males, VWD affects both men and women equally. Despite who it affects, the cause behind this disorder lays on the shoulders of one specific gene,

There are two types of Hemophilia, type A and type B, Hemophilia A is associated with blood clots after injury or a type of surgery, Hemophilia A is a disease in which a type of protein that is used to stop clotting is changed or mutated. This all starts after the bleeding has begun, little molecules send out a signal for a protein called factor 12 to be activated, then this protein goes on to activate other proteins till the protein Fibrinogen is activated which stops the bleed and forms a stable clot, but, when Hemophilia is brought in, this can cause major problems. It occurs in the factor 8 gene. Hemophilia causes this gene to be mutated, which is located on the X chromosome. The instructions for making the gene are altered which makes the protein changed as well. In a minor case only a small part of

Based on the information given, the child's probable diagnosis is Hemophilia. Hemophilia is a genetic disorder that prevents blood from clotting properly. Clotting helps stop bleeding after a cut or injury. Without clotting, a wound can bleed too much either internally or externally. (“Bleeding Disorders in Children,”n.d.) According to Griffin (Griffin, 2015) Hemophilia mostly affects boys (about one in every 5,000-10,000). Girls who inherit the gene rarely get the condition, but become carriers of the gene and may pass it on to their children.

You mentioned hemophilia so I just wanted to explain what it was. Hemophilia is an inherited disease that affects the clotting process of your blood. Therefore, if you have hemophilia you do stand a chance of sever bleeding if you incur an injury or cut. There is a protein that is called clotting factor that a person might have little or none at all. It is a protein used for blood clotting that helps blood platelets stick together. (NIH

Hemophilia is an inherited bleeding disorder that is passed from mother to son. This affliction is passed in such a way due to the fact that the gene that is responsible for hemophilia is carried on the X chromosome that the child receives from his mother. For someone to be afflicted by hemophilia means that their blood has a difficult time clotting. There people do not bleed any faster than the average person, they simply cannot stop bleeding once they start bleeding. As of this current moment, there are no known cures for hemophilia, but there are many treatments that are highly effective in helping to treat many of the issues associated with the bleeding disorder. (citation)

Hemophilia is the most common X-linked inherited bleeding disorder caused by deficiency of coagulation factors VIII (Hemophilia A) and IX (Hemophilia B) [1]. Hemophilia A has a frequency of 1 in 5000 male births, while hemophilia B has a frequency of 1 in 30,000 male births [2]. The severity of the bleeding in hemophilia depends on the level of clotting factor activity [3].

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

Hemophilia is a bleeding disorder that slows down the blood clotting process. People who have hemophilia often have longer bleeding after an injury or surgery. People who have severe hemophilia have spontaneous bleeding into the joints and muscles. Hemophilia occurs more commonly in males than in females.

Blood, it flows through every human’s circulatory system, and carries with it the essential ability to clot, or become thicker, which prevents excessive bleeding for a laceration. This clotting is caused by proteins in the blood, specifically the proteins known as coagulation factor VIII and coagulation factor IX, which work with tiny particles called platelets to form the clot. However, in a rare genetic disorder known as Hemophilia, these clotting proteins are either missing from the blood or found in lower does than in the blood of the average human. This causes the patient’s blood not congeal properly when a laceration occurs, which can put the patient at risk of exsanguination, or death by loss of blood.

Have you ever wondered about diseases? Today’s disease is called Hemophilia. Hemophilia has many symptoms, problems, and medical treatments. Hemophilia was discovered by Dr. Judith Pool. Hemophilia is a rare disease. It prevents cuts and wounds from getting clotted properly. “The platelets are not sticky enough for the wound to be sealed”. This disease usually leads to lots of blood loss. There is no cure, but there are treatments. “There are two types of Hemophilia, Hemophilia A and Hemophilia B one being rarer than the other.” “The way you get Hemophilia is if your parents had it and you inherited it”. Hemophilia is called the “Royal Disease” it dates back to 1800’s when Queen Victoria was queen. She then passed the disease to her daughters. “When the daughters decided to get married and have children they then passed the disease to their children and husband which then spread like crazy.” Which today it is known as hemophilia.

Hemophilia is a very serious bleeding disorder affecting humans all over the world (Mc Partland, 2016). People suspected to be affected by the disorder normally portray physical features associated with either excessive bleeding or easy bruising. The symptoms of the disease are different depending on the type of hemophilia and also the level of the disorder for example severe hemophilia is associated with excessive bleeding after injuries (Zerwekh, Miller, & Claborn, 2012). The degree of

Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.