Waldenstrom Macroglobulinemia Essay

Multiple myeloma (also plasma cell myeloma also known as MM, myeloma, plasma cell myeloma, or as Kahler's disease) is a progressive hematologic (blood) disease. It is a cancer of the plasma cell, an important part of the immune system that produces immunoglobulins (antibodies) to help fight infection and disease.

It still consists of asthma type medications, oxygen, augmentation therapy, and lung and liver transplants. They have more clinical trials to try out more medications on the market to see if any of them may be helpful. So far the best treatment seems to be the lung transplant, but again, you have to be sick enough to receive it but healthy enough to live life afterwards. Both my mother and uncles Alpha One were so progressive and severe, a lung transplant was out of the question. I could not imagine the pain they went through daily plus knowing that your life would be cut short would be almost unbearable.

neoadjuvant chemotherapy, the tumors are very aggressive and associated with a poor prognosis as well as a

The diagnosis of multiple myeloma can occur after a routine blood test with your doctor. However, the most common diagnosis occurs when doctors take an x-ray of a broken bone and suspect the cancer has caused or is a contributing factor to the broken bone. When analyzing the blood tests, the following are considered when diagnosing multiple myeloma: people with multiple myeloma have high levels of proteins in the blood, especially M and other immunoglobulin, albumin, and beta-2-microglobulin. Also, the blood exam tests for high levels of calcium and for creatinine levels (to assure that the kidneys are working properly).3 Other ways to test for multiple myeloma include urine tests, x-rays, biopsies (test the bone marrow itself from a large bone - a painful procedure). Unfortunately, Multiple myeloma is a very fatal cancer, where only 35% of patients diagnosed with multiple myeloma living 5 years past their diagnosis.3

Primary treatments include antibiotic therapy, Fluid resuscitation, and crystalloid. Potential treatments depending on patient status include vasopressors and steroids, ventilator, renal dialysis, blood transfusion, and surgery.

Scenario: John is a 4 year-old boy who was admitted for chemotherapy following diagnosis of acute lymphoblastic leukemia (ALL).  He had a white blood cell count of 250,000.  Clinical presentation included loss of appetite, easily bruised, gum bleeding, and fatigue.  Physical examination revealed marked splenomegaly, pale skin color, temperature of 102°F, and upper abdomen tenderness along with nonspecific arthralgia.

There are many ways to treat this condition. Treatment can depend on the size, location, and stage of the tumor. Often, more than one type of treatment is used. Treatment may include:

Like many cancers it is triggered by mutations in the p53 protein gene and tends to spread quickly through the lymphatic system if not destroyed. Treatment most involves surgical removal in early stages and immunological treatment at latter stages.

The name often refers to just the cancerous ones rather than all such tumors. Symptoms may include enlarged lymph nodes, fever, drenching sweat, weight loss, itching, and feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night.

very sad for my family and I. My mom whom was diagnosed with the on-set of the disease in

There are many treatments to help with keeping people healthy and extending the life expectancy for this disease. One of the treatments

Multiple myeloma (MM) is a rare life-threatening cancer that affects the white blood cells known as plasma cells that are found in the soft, spongy tissue at the center of the bones, called bone marrow. The plasma cells are useful in fighting infections by producing antibodies that recognize and attack germs. The plasma cells are transformed into malignant myeloma cells when there are high levels of M proteins or better known as the production of abnormal antibodies from a result of myeloma cells. These M proteins multiple and block out normally functioning antibodies and the end results are bone damage or kidney problems. An individual can have blood tests or urine tests done to determine if they have multiple myeloma. In the article, “The work of living with a rare cancer: multiple myeloma” the authors explain how this type of cancer still remains incurable, but treatable that patients can expect to live longer, approximately five to seven years than what two decades ago. This was not expected for patients diagnosed with multiple myeloma during the 1990s, since patients were expected to only live about two and a half years after being diagnosed. Treatment for multiple myeloma throughout the years has advanced greatly yet a cure is still to be discovered. This essay will focus of the causes, the sign and symptoms, how multiple myeloma is detected and diagnosed, and how multiple myeloma is treated.

There is no cure for the disease but there is a treatment for the symptoms. There are only 5 drugs that are currently available that the FDA has approved.

James is a 74-year-old male who is diagnosed with Waldenstrom macroglobulinemia (C88.0), along with bipolar disorder and anxiety. James is status post splenectomy, roughly about 10.5 years, along with taking Ibrance, but still experienced aggressive disease progression. His most recent PET/CT scan concluded diffuse new hypermetabolic metastases involving the left palatine tonsil, lingual tonsils, multiple cervical, mediastinal, axillary, retroperitoneal, intrapelvic and left inguinal lymph nodes, with a new 8.4 cm metastasis located medial to the left kidney, resulting in moderated left hydro nephrosis, and a new right perirectal metastasis. James is also experiencing weight loss, fatigue, loss of appetite, depression, abdominal pain, constipation

     Future treatments for the disease are as follows. In the future people may be able to inhale insulin rather than take painful injections. There are also