What Are Polycystic Ovarian Syndrome ( Pcos ) Is The Most Common Endocrine Disorder?

3279 Words Mar 30th, 2015 14 Pages
Abstract

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder diagnosed in women of reproductive age. The disease manifests itself with varying symptoms and has long term consequences of heart disease, diabetes, and infertility. PCOS has no clear etiology or pathophysiology, and as new information is being contributed, the mechanism and components of the disease is being updated. Presented here are the most understood and accepted components of PCOS, and its pathology as a reproductive disorder along with its endocrine and metabolic relationships. PCOS pathophysiology exhibits itself mainly through increased androgen synthesis through ovaries and adrenal glands causing follicle growth to halt in the antral stage. Its etiology has been determined to be multifactorial with both genetic and environmental factors causing or increasing effects. Genetics of PCOS have shown its transmission to be in autosomal dominant fashion while environmental factors such as obesity, insulin resistance, and intrauterine environment contributes to its phenotype. Relationships between the factors are discussed and how they contribute to the overall phenotype.

Introduction

Polycystic ovarian syndrome (PCOS) is a hormonal endocrine disorder that causes an increase in androgen production primarily from the ovaries. Affecting 10% of women between the ages of eighteen through forty-four, it is one of the leading causes of infertility in women and one of the most…
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