What Is Bk Virus? Essay

2174 WordsSep 20, 20169 Pages
verview 1. What is BK virus? BK polyomavirus (BKV) is a non-enveloped and circular double-stranded DNA virus in the Polyomaviridae family. BKV has a genome of approximately 5100 nucleotides [1] that is packed by host-cell histones H2A, H2B, H3 and H4, thereby forming a minichromosome [2, 3]. It was first isolated in 1970 from urine collected from a renal transplant recipient whose initials were B.K. It causes symptomatic and asymptomatic human infection [4]. After primary infection, usually acquired asymptomatically in childhood, BKV remains latent in many sites, particularly in the renourinary tract [5]. BKV reactivation is observed following immunosuppression, such as in organ transplant recipients [6]. BKV is popular problem in renal transplant recipients, with disease is linked to the degree of immunosuppression [6]. Manifestations include organ damage or allograft rejection, although renal BKV infection is usually subclinical [6]. BKV may cause ureteral stenosis and nephropathy in renal transplant recipients, and recent studies have shown that 1-10% of renal transplants demonstrate BKV replication that induced graft inflammation [7, 8]. Virology 1. Structure BKV is about 50 nm in diameter. Its capsid comprises 72 capsomers, each consisting of pentamers of the VP1 protein, and one internal minor protein, either VP2 or VP3, linking the circle double-stranded DNA genome to the capsid [9]. All polyomaviruses possess three structural proteins: VP1, VP2, and VP3, with VP1
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