What Is Iron Overload?

Iron Deficiency Anemia affects millions of individuals across the world. This disease strikes many more women than men and has harmful effects on all who suffer from this deficiency that causes oxygen-carrying capacity to decrease. The causes can vary amongst different groups, but the aggravating symptoms remain constant. Much of the research on Iron Deficiency Anemia concentrates on not only the treatment of this disease, but also the prevention of it. To attain a better understanding of how to treat this problem, one must clearly know what Iron Deficiency Anemia means, what causes this disease, the effects of it, and finally how to cure it.

Hemochromatosis is a genetic disease in which there is too much iron that builds up in your body, this is referred to as an iron overload. Iron is an essential nutrient found in many foods but can be toxic to our bodies if we have to much. “Normally, humans absorb about 8-10% of the iron found in foods that they eat.” People with Hemochromatosis can absorb up to four times more iron than a normal human being. Since our bodies have no natural way to get rid of the extra iron, it gets stored in your body tissue including the liver, heart, pancreas and many other areas of our body can also be infected by this iron overload.

Typically, when a human body has a sufficient amount of iron, it will reduce its intake of iron. However, within certain bodies, it is always under the impression that there isn’t enough. Thus, it continues to absorb more iron and this iron overload is the result of a disease called hemochromatosis. Generally, the excess iron builds up in the joints, liver, heart, and other organs which can lead to symptoms that include physical difficulty, joint pain, and an irregular heartbeat. However, the symptoms alone is not enough when it comes to diagnosing hemochromatosis. Therefore, taking part in blood, liver, and/or DNA testing will be more accurate. After diagnosing hemochromatosis, people can undergo treatments such as the medical procedure called bloodletting. By

Dr. Moalem explains that hemochromatosis is a hereditary disease prominent in genes of descendants of western Europeans, and the disease causes an overflow of iron in the body while macrophages end up with less iron (2, 12). He further states that macrophages lacking in iron prevent infections from obtaining iron, and successfully starve off those same infectious agents (Moalem 13). Dr. Moalem believes that this diseases is present in the genes of many humans today since the body can then lock iron in order to defend the body’s systems, thus preventing immediate disease but also long term health problems.

Markers of iron status suggest a lower prevalence of iron deficiency in the MSC compared to local controls: transferrin saturation <16% = 25% [N=835] vs 47%[N=79] in controls. Moreover, our data suggest that higher iron status (but not iron overload) assessed by transferrin saturation is associated with lower daytime and nocturnal haemoglobin oxygen saturations [36]. Transferrin saturation is not associated with haemoglobin concentrations in SCD cases, compared to a strong correlation in the non-SCA controls, whilst adequate iron status assessed by the F-index (ratio of soluble transferrin receptor to logged ferritin), is paradoxically associated with greatly increased odds of having averaged steady state haemoglobin concentrations in the lowest septile (RR=5.45 [2.71/10.96] P<0.001). Hence iron will not be included in the fortificants of the current intervention.

Iron-refractory iron deficiency anemia results from an inadequate amount (deficiency) of iron in the bloodstream. It is described as "iron-refractory" because the condition is totally resistant (refractory) to treatment with iron given orally and partially resistant to iron given in other ways, such as intravenously (by IV). In people with this form of anemia, red blood cells are abnormally small (microcytic) and pale (hypochromic). The symptoms of iron-refractory iron deficiency anemia

Hemochromatosis is a genetic disorder where you body absorbs excess iron from the food that you eat. Your body then stores the excess iron in your crucial organs like your heart, brian, pancreas, and liver. Your body also stores the iron in your joints. If too much iron were to accumulate in any of your vital organs it could lead to organ failure and even

Presumed to have been plaguing humanity since the Viking era, hemochromatosis is a fatal hereditary disease that upsets the body's natural metabolizing of iron. The mineral, although essential to the survival of all living organisms, becomes extremely lethal in abnormally large quantities. Unfortunately, this serves as rather tragic news to those afflicted with the disease, since their bodies absorb iron in an uncontrollable manner. Various medical complications and consequences, including cancer, infertility, psychiatric disorders, diabetes, arthritis, and damage in the joints and overall body chemistry, could eventually occur over a long period of time. Hemochromatosis furthermore attacks major organs such as the heart and liver, and

I was surgery last month. After surgery, my doctor told me I had an amount of blood. So, I felt very tired. I become more interested in anemia. Accordingly, I had picked iron deficiency anemia. According to the Health line, anemia occurs when I have a level of red blood cells (RBCs) in my blood that is lower than normal. They explained iron deficiency anemia that is the most common type of anemia, and it occurs when my body do not have enough of the mineral iron. My body needs iron to make a protein called hemoglobin. This protein is responsible for carrying oxygen to my body’s tissues, which is essential form my tissues and muscles to function effectively. When there is not enough iron in my blood stream, the rest of my body cannot get the

Iron is a vital mineral that is needed for many roles within the body. This includes the transport of oxygen in the blood with haemoglobin, myoglobin which is iron-containing and helps store oxygen in muscles cells and support of the immune system (Arens, 1996).

Final Question: In patients with non-dialysis-dependent (NDD) Chronic Kidney Disease (CKD) who have iron-deficiency anemia, how efficacious is intravenous (IV) ferric carboxymaltose in increasing hemoglobin levels and reducing treatment-related adverse events compared to IV iron sucrose?

Iron Deficiency Anemia (IDA) is the most common form of anemia worldwide. It occurs when the body is lacking iron. Iron is important to all cells, but especially to the red blood cells (RBC’s), as they make hemoglobin, which carries oxygen to the tissues in the body. Normal iron levels for a female are 40-150 ug/dL, and 50-160 ug/dL for males.

I know first hand what its like to have iron deficiency anemia. I have had it for almost four years and I know what its like to not even know when you have it. I was diagnosed with anemia when I fainted in a movie theater after loosing a very large amount of blood from my menstrual cycle. I knew it wasn’t normal, but I was not aware of how serious it actually was . I began to have symptoms a few hours before going to the movies, but I did not pay much attention to it. After the incident in the theaters, I was rushed to the hospital and that is when they diagnosed me with iron-deficiency anemia.

Since the body is unable to metabolize high doses of iron, the excess iron intake start to irritate the lining of the gastrointestinal tract of the body leading to a variety of problems

The main cause of iron-overload disease is the mutation in the gene that is located in the sixth chromosome, exactly in the short arm. The mutation is called C282Y. Moreover, ferritin is a protein and“…most of the iron stored in the body is bound to ferritin. Ferritin is found in the liver, spleen, skeletal muscles, and bone marrow. Only a small amount of ferritin is found in the blood” (WebMD, 2014). The amount of ferritin in the blood shows how much iron is stored in the body. Therefor accumulation of iron that is associated with ferritin protein provoke what is called Iron overload or haemochromatosis.