What Is Pharmacokinetics?

During Phase 1, sufficient information about the drug’s pharmacokinetics and pharmacological effects should be obtained to permit the design of well-controlled, scientifically valid, Phase 2 studies.

In our experience with Pharmasim we learned that Marketing decision making must be very sensitive and responsive to everything going on in the industry which is very complex. Consumer responses to marketing tactics can be volatile and unpredictable and no idea is guaranteed to work well. Marketing is a matter of meticulous research, assumptions, planning, and volatility at times. Overall we took away two major points: 1) that it is important to consider the product lifecycle in evaluating how to promote businesses and, 2) that the “Sweet Spot” as a competitive advantage should be the greatest point of consideration when evaluating how to best gain leverage to beat the competition in the minds of

* Origin of Drug: Dutch word droog meaning dry for dried herbs and plants that were the 1st medicine.

An elderly patient is complaining of a bad cough at her yearly physical. She has recently been diagnosed with diabetes and regularly takes prescription pain medication for her arthritis.

Absorption – “How the drugs enter the circulation process through the body, and how they resist general breakdown by the stomach, liver, and the intestines”. Some of the factors that affect the absorption of drugs in the body is as follows, “acidity of the stomach, Physiochemical properties, Presence of food in the stomach or intestine, and Routes of administration”,

Pharmacokinetics "is the way a drug is absorbed, distribution, metabolism, and excretion (pg. 749 Treas)

Patients walk into our clinics daily with a variety of complaints. Many things we can observe and assess drive our decisions for plans of care. However, there are some things about our patients we can’t see. Some things nobody would know under normal circumstances. How most medications are metabolized is predictable across the population, but some medications throw us a curve ball. Polypharmacy is a necessity in primary care. As primary care providers (PCPs) we see patients for both chronic and acute pathologies. Understanding metabolic pathways is expected of us as providers, but that doesn’t make us invulnerable to poor outcomes despite best efforts. In the following

breakdown of drugd within the body and the characteristic interactions of a drug in terms of its

Topical drugs such as patches, ointment, and cream are applied directly on the skin and can be absorbed fast or with a delayed action. The term pharmacokinetics is the study of the movement of the drug in the human’s body. This includes the site of absorption (movement of drug from entry to tissue), how it is distributed (movement in the circulatory system to intended destination), how it is metabolized (break down in the liver), and excretion (elimination from the body). This unit also described the term half-life, which is how long the human body takes to break down a drug, absorb and excrete it and short half-life, which are medications excreted by the body quicker than long half-life drugs. The term pharmacodynamics is any of the changes in the patient’s body resulting from the medicine taken. It is highly important for the patient to know of the used drug’s side effects (unintended effects), adverse effects (unintended effects that can be harmful), and any possibilities of allergic reactions (most severe adverse response of a

They design the drug therapy protocol and indicate the appropriate dosage to use so that patients get the optimal outcome of the medication. Clinical assessments are vital to test the efficiency and the safety of an existing medication specifically through therapeutic drug monitoring. This practice is known to provide effective pharmacologic therapy though producing the maximum benefit of a drug which can remain longer period of time within the patients and have almost no toxicity that could cause harm to patients. This is why therapeutic drug monitoring in the field of pharmacy is essential enough to figure out an effective medication against a disease without any dangerous toxic actions involved to improve patients’ quality of life and hopefully find exceptional cures which is one of the pharmacists’

Pharmacokinetics consists of three components, absorption, distribution, and clearance. Absorption, especially from the oral route is the least influenced by the aging process and slows down, but remains complete (Adams et al., 2011). As the number of drugs ingested increases, the risk that absorption is interrupted increases (Adams et al., 2011). Distribution is significantly impacted with age. Older people have more body fat and less water than younger people. As a result, a drug that is fat soluble will remain in older bodies

This subject interest me because when I was younger I was struck by a truck and while in the hospital I asked the nurse what medication they were using for pain management. She said she was using a water solution to be administered by IV because I had lost a lot of blood and fluids. I wondered why do I need more fluids and why it had to be administered by vein instead of the mouth. She sums it up to that the medications couldn’t be taken by mouth because the doctors need to had to make sure the liquid enter in the bloodstream and that it reacted quickly. Ever since then I always asked how these medications break down in the body to perform a specific task. I believe that I am suitable for this course because I have believed I have great problem-solving skills and scientific

Pharmacodynamics is the study of how a drug reacts on a living organism. Pharmacodynamics with pharmacokinetics helps explain the relationship between the

As mentioned in class, as well as in the required Krishna (2008) article, the drug development and approval process is an extensive and costly endeavor. The goal of experimental medicine is to increase the efficiency of drug development by providing a better understanding of the drug’s mechanism(s) of action, dose response, efficacy, and safety, allowing the process to be accelerated for the most promising and efficacious candidates (Krishna, Herman, & Wagner, 2008).

Pharmacology is the branch of medicine and biology that seeks to understand drugs and how they affect the body. It involves the analysis of how drugs interact with the biological function of the body and how these drugs react with each other, their natures, and their properties. All drugs are considered chemicals and when ingested into the body an affect from the drug takes place. According to Doweiko (1999), “A drug is essentially a foreign chemical that is introduced into the individual’s body to bring about a specific desired response. There are many forms of drugs and how these drugs are administered in the body determines the kind of result that will take place. The Central Nervous System, (CNS) plays a major role in how these