What Is Pharmacokinetics?

1220 WordsFeb 20, 20185 Pages
Pharmacokinetics is a branch of pharmaceutics devoted to determine the fate of substances administered externally to in a living organism1. Pharmacokinetics attempts to discover the fate of a drug from the moment that it is administered (T initial) until the point at which the substance is completely eliminated from the body (T final). The substances could include any of the followings; pharmaceutical agents, hormones, nutrients, and toxins1. In order to measure the PK parameters a number of different models have been developed. These models can be used in order to understand the many processes that occur in the interaction between an organism and a drug. These models include; one compartment model and multi-compartment model are used. The multi-compartment model, gives the best approximation to reality, however, the complexity involved in using this type of model means is above all other models. The basic compartments that each model is divided into are commonly referred to as the ADME scheme2. Noninvasive sampling method allow us to study the human samples without the need to isolate or even make them uncomfortable, and thus allows questions to be addressed that cannot be answered using conventional methods5. This sampling strategy promised to exploit fully the concentration of the drug in the feces or in urinea and then be able to calculate the drug concentration in plasma. However, recent work now indicates this sampling method requires a more cautious approach,
Open Document