What Is The Cause Of Huntington's Disease

The genetic disorder is caused by a mutation in the DNA segment CAG found in chromosome 4 which results nerve cell death. Phenotypic characteristics include gradual motor dysfunction, psychological issues that correlate to degeneration of metal health, and cognitive degeneration. Studies on transgenic mice have allowed a better understanding of the proteins that relate to Huntington’s

4. “Huntington Disease - Genetics Home Reference.” U.S. National Library of Medicine, National Institutes of Health, ghr.nlm.nih.gov/condition/huntington-disease.

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

“An Interview with Dr. Nancy Wexler: Discovering the Huntington Disease Gene.” HD Insights, Huntington Study Group, 2012, chrome-extension://ecnphlgnajanjnkcmbpancdjoidceilk/content/web/viewer.html?source=extension_pdfhandler&file=http%3A%2F%2Fhdsa.org%2Fwp-content%2Fuploads%2F2015%2F02%2Fhd-insights-volume-3.pdf. Accessed 15 Dec. 2017.

Adolescents at risk for Huntington’s Disease should undergo predictive genetic testing to maximize their enjoyment of life as a healthy individual. Although fatal, Huntington’s Disease is not an immediate death sentence. People can usually continue to function normally for many years if the disease is diagnosed in adolescence. Testing for Huntington’s Disease can end uncertainty and allow adolescents to make informed decisions about the rest of their lives in order to make better use of the time that they have as a healthy person.

Huntington’s Disease is a dominant, autosomal, neurodegenerative disease that results from excess CAG repeats on the human chromosome 4. These CAG repeats code for a protein named Huntingtin, and patients of Huntington's Disease have a mutated form of it. Symptoms begin to appear in one’s middle ages and continue to progress over a span of about 20 years. It leads to loss of mental ability and muscle coordination, as well as increasing one’s vulnerability to depression. Those who develop Huntington’s Disease cannot be cured, but there is treatment to reduce the mental and physical effects. Genetic advancements in both testing and treating Huntington’s Disease have provided hope for families with a history of this disease, but it has

Huntington’s disease is an inherited disorder of the central nervous system, and the degeneration of nerve cells in the brain, which causes the brain to deteriorate.

Huntington 's disease is an inherited neurodegenerative disease that is caused by a mutation on the HTT gene. It typically effects persons in their third to fifth decade of life and can be passed onto their children. Neurons in the brain waste away or degenerate in different areas causing the characterizing symptoms, such as dance-like movements and mental decline. Diagnosis and prognosis can be devastating to both individual and family. However, there are genetic tests that can help to predict the probability of developing symptoms of the disease. There is no cure for this debilitating disease; only symptom control and maximization of comfort can be prescribed until future research finds a cure. This paper will review origins and symptoms, in addition to treatments and future treatments.

For our gene and protein lab, my group decided and I to research the deadly, yet rare, disease, known as Huntington's disease. Huntington's disease is an extremely rare condition when your nerve cells in your brain break down overtime. Also, “HD” has a treatment that could aid someone, but it unfortunately cannot be cured. Huntington’s Disease typically begins when someone is thirty or forty years of age and can last years to a life time.

Named after George Huntington, Huntington’s Disease is a hereditary neurodegenerative disease. It “causes the death of specific neurons in the brain, leading to jerky movements, physical rigidity, and dementia (First).” The mutation was first mapped to chromosome 4 in 1983, becoming the first disease gene to be mapped using DNA polymorphisms (First). In 1993, a group of investigators found the gene that causes Huntington’s Disease. It is caused by a mutation in a gene located on chromosome 4 (Mennitto). The gene contains an abnormally large number of CAG (Mennitto). The gene may lengthen when passed from father to child, but not mother to child (Mennitto).

Huntington’s Disease is a progressive brain disorder caused by a single defective gene on chromosome 4.

genetic disorder that many are unaware of or oblivious to the detrimental effects it can have on someone. This disease was named after Dr. George Huntington due to his discovery of these weird movements that were found in patients with this disease (Genetic Science). Approximately one in thirty thousand people in the United States currently have this disease in the United States (Genetic Science). For many, that may not be much of a number compared to other cancers and genetic disorder, but considering the detrimental symptoms that greatly shorten one’s life in this disease, it is a serious problem. In fact, patients with Huntington’s have proteins that accumulate in one’s brain, becoming toxic and eventually resulting in cell death

Huntington’s disease causes the breakdown of nerve cells in the brain. It affects the nervous system and is hereditary. As an Autosomal Dominant disorder, it only needs one copy of a faulty gene to develop the disorder. It has been assessed that Huntington’s disease influences around 10.6 and 13.7 for each 100,000 people in the European society. In the American society, 1 in 10,000 will have the disease and furthermore approximately 150,000 Americans also have the 50% chance of developing the illness. It is very common in European descent, however appears to be uncommon in Asian populations. This report will explain how it is caused, the signs and symptoms and how it affects an individual, furthermore it will be explaining

Huntington’s Disease (HD) is a late-onset, chronic neurodegenerative disease characterized by impairments in motor, cognitive, and psychological functions. It is caused by a mutation in Exon 1 of the IT15 gene, which encodes the huntingtin (Htt) protein. Mutant huntingtin (mHtt) has an expanded CAG repeat in its N-terminal region, encoding a poly-glutamine (polyQ) track that can either form toxic aggregates in neurons or interact with various cellular proteins, leading to altered cellular processes and neuronal apoptosis. In HD, the loss of inhibitory medium spiny neurons within the striatum causes involuntary movements characteristic of the disease; These neurons are involved in refining the excitatory outputs of the cerebral cortex, which

Huntington’s disease is a brain disorder, which is passed down from one generation to the next through irregular genes. Children who have parents suffering from Huntington’s disease have a 50% chance of having the gene that can later develop into the disease. The irregular genes are caused by a copying error in which a part of the gene is copied too many times. The disease slowly kills brain cells and causes a gradual progression in symptoms. Symptoms include things such as psychosis, hallucinations, involuntary movements, difficulty understanding things and confusion. In the early stages of Huntington’s disease symptoms are manageable, however as it progresses symptoms worsen and individuals can suffer memory loss and personality changes.