What´s Stopping Theoretics?

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Several stopping criteria have been developed and applied so that a trial can be stopped earlier because either the treatment works or the treatment does not work. They are based on either the posterior density of the response probability, or the predictive distribution of the number of hypothetical responses from m additional patients [Stallard et al., 2001; Tan et al., 2001; Farge, 2002; Zohar and Chevret, 2001; Chen and Chaloner, 2006]. Zohar et al. (2008) listed some stopping criteria as follows:
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