synthesised from aldehydes and ketones using the Wittig reaction. The Wittig reaction facilitates the synthesis of new carbon-carbon double bonds at specific locations in aldehydes and ketones (Bernard & Ford, 1983). The overall reaction mechanism is shown in Figure 1. Protocols for synthesising 1,3-butadienes from aldehydes and ketones have been established in the literature. The synthesis protocol proposed by Greatrex et al. (2014) was used and reactions using several aldehydes (cinnamaldehyde, piperonaldehyde
Preparation of 3-(2-Nitrophenyl)acrylate Utilizing the Wittig Reaction Introduction: The Wittig reaction, named after Georg Wittig, produces an alkene from an aldehyde or ketone reacting with a phosphonium ylide (a Wittig reagent). The Wittig reaction is typically stereoselective, which makes the Wittig reagents more difficult to work with but use of the Wittig with different allyl substituents prove to make the Wittig more versatile which can lead to the synthesis of a wide range of alkenes, styrenes
The purpose of this experiment was to perform a wittig reaction, the horner-emmons wittig specifically, reacting an aldehyde with an ylide to make an alkene. This particular variation of the wittig reaction has several advantages: It gives only the trans product; it uses a much milder base that is easier to handle; and it gives a water soluble byproduct which is easy to separate from the product. The reason that these advantages occur is a change in the structure of the ylide. Instead of a tripheylphosphine
TRANS-9-(2-PHENYLETHENYL) ANTHRACENE (A WITTIG REACTION) Introduction: The purpose of this experiment is to convert carbonyl compounds to alkenes using Wittig reaction. In this case we will be synthesizing Trans-9-(2-phenylethenyl) anthracene from benzyltriphenylphosphonium chloride and 9-anthraldehyde. We will also aim to obtaining a high percent yield and purity for the synthesis of Trans-9-(2-phenylethenyl) anthracene. The mechanism for this reaction goes thus: Experimental:
The Wittig reaction is a chemical reaction of an aldehyde or ketone with a triphenylphosphine ylide to give an alkene and triphenylphosphine oxide. Synthesis of Wittig Salt done using 1.334moles triphenyl phosphine and 1.334moles of methlyiodide using toluene as solvent charged in a 5L RB under N2 atm at temperature maintained at 25-30°C and kept overnight. Reaction mixture filtered under vacuum and washed with toluene, dried at 70-75°C for 5-6 hr. The amount of Wittig Salt obtained =517g
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