Hemophilia describes a group of sever congenital coagulation factor deficiencies. It is a lifelong genetic disorder with a prevalence of 1:10,000 birth and that of the most severe form of the disease to be approximately 6% per 1,00,000 Population (1). Depending on the activity of coagulant factor VIII or IX in blood, hemophilia may be labeled as severe (<1% of normal), moderate (1–4%) or mild (5–25%) (2) . hemophilia is characterized by recurrent haemarthroses inside the less muscular padding joints as knees, elbows and ankles joints (3).
Because immature cartilage is even more susceptible to spontaneous bleeding, most of hemophilic children experience repeated episodes of hemorrhage into their joints (4). Intra-articular bleeding of synovial joints has a direct destructive effect on cartilage which triggers the joint degenerative process (5) and impact on the total motor development of children and youngsters (6). Patients with hemophilia often used to have a sedentary lifestyle because of repeated uncontrollable hemarthroses with subsequent
…show more content…
Yet, to date and to our knowledge, there are no studies on balance improvement approaches for children with hemophilia. In the past few years, it has been suggested that sensorimotor training contribute to reflective activation of the deep postural muscles and challenge the sensorimotor system to restore normal control of individual segments during dynamic tasks(17-19). Although many therapists and clinicians reported successful treatment cases, the exact effect and validity of sensorimotor interventions is still discussed with contradicted results (20-22). Therefore, this study aimed to investigate the feasibility and efficacy of sensorimotor training on improving balance performance and pain in children with
According to the National Hemophilia Foundation (.n d.), people with VWD experience recurrent nosebleeds, easy bruising and extreme bleeding for the duration of and after invasive procedures, such as tooth removals and surgery. Women often experience menorrhagia, heavy menstrual periods that last lengthier than usual, and hemorrhaging after giving birth. The signs and symptoms depends on the severity of the disease.
Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those
Hemophilia is a condition where a person's blood is unable to clot properly. This condition can make a simple dental procedure more risky. People who have hemophilia will also have a harder time healing after a dental procedure. You definitely want to let your dentist know if you have hemophilia.
Olama, K.A., & Thabit, N.S. (2010) performed a randomized controlled trial to determine the efficacy of whole body vibration (WBV) and a designed physical therapy program versus suspension therapy and the same designed physical therapy intervention in balance control in children with hemiparetic CP. Criteria for inclusion for the study were children with hemiparesis cerebral palsy from both sexes ages 8 to 10 years old, able to understand commands given to them, able to stand and walk independently with frequent falling, and balance problems ( as confirmed by the Tilt Board Balance Test). The exclusion criteria consisted of presence of any medical condition such as vision and hearing loss, cardiac abnormalities, and musculoskeletal disorders. Children who met the criteria (n=30) were recruited from the outpatient clinic, College of Physical Therapy, Cairo University The randomization was done according to the Gross Motor Function Classification System (GMFCS). Treatment allocations were done by the selection of a closed envelope randomly selected. Parents and children were informed of the treatment allocation after the selection, procedures were explained to both of them and signed assent and consent were obtained.
A. It 's important to know that hemophilia is not actually a disease or virus. https://my.clevelandclinic.org calls hemophilia "a rare hereditary (inherited) bleeding disorder in which blood cannot clot normally at the site of a wound or injury". This means that it is not contagious, rather it is passed down through genetics. When a hemophiliac gets injured,
Hemochromatosis is a genetic disease in which there is too much iron that builds up in your body, this is referred to as an iron overload. Iron is an essential nutrient found in many foods but can be toxic to our bodies if we have to much. “Normally, humans absorb about 8-10% of the iron found in foods that they eat.” People with Hemochromatosis can absorb up to four times more iron than a normal human being. Since our bodies have no natural way to get rid of the extra iron, it gets stored in your body tissue including the liver, heart, pancreas and many other areas of our body can also be infected by this iron overload.
Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.
Listing from blood in the urine to nosebleeds and many others. More symptoms include deep bruises, blood in stool, excessive bleeding, pain in joints, and tight joints. Hemophilia is usually inherited which means that the parents pass the disease to their offspring. It is caused by a pairing up with a hemophilia gene if the mom has a normal clotting and the dad doesn’t he has the hemophilia gene. However if they have a child the child will not have hemophilia because the mom is dominant over the dad. It would be a genetic tendency because the mom and dad have genes that will join together and determine to see if their child will have
Hemophilia A, the most common, involves decrease factor VIII protein, an essential blood clotting protein also known as anti-hemophilic factor. There are three levels of factor VIII protein deficiency, severe, moderate, and mild. Hemophilia A has three levels of classified based on the percentage activity of the normal factor VIII protein. Having less than 1% of the normal factor VIII activity have severe hemophilia. Half of the individuals with hemophilia fall into this category. These individuals afflicted with type A Hemophilia experience spontaneous bleeding, most frequently into their joints, skin, and muscles. Individuals with this Hemophilia are very fragile and surgical procedures or trauma can lead to severe hemorrhage and can be life threatening if not treated. Individuals with 1-5% normal VIII protein have moderate hemophilia and can be at risk of heavy bleeding after minor traumatic injury. If an individual affected with Hemophilia A have 5-40% normal factor VIII then they have mild hemophilia and they have to be careful with any surgery or dental procedure. Hemophilia B is similar to Hemophilia A, but instead of having deficient factor VIII protein an individual plagued with Hemophilia B have a deficient factor IX protein a serine proteases of the coagulation system (R. Jenkin, 41). Hemophilia C, the rarest Hemophilia, is more mild than the other two hemophilia’s and involves factor XL or plasma
Introduction: Flexion contracture (FC) is a commonly encountered deformity in patient undergoing total knee arthroplasty (TKA). Hemophilic arthropathy of the knee joint is the most common joint involvement in patients with hemophilia which often leads to FC. Clinical course of FC after replacement of an osteoarthritic knee is well reported in the literature. However, to our experience in a high volume referral center, the course may be different in patients with hemophilic arthropathy.
Hemophilia is a blood disorder that’s usually genetically inherited from parents. People born with hemophilia have little or no clotting factor – a protein needed for normal blood clotting.
Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.
Hemophilia is a rare disorder in which your blood doesn 't clot normally because it lacks sufficient blood-clotting proteins known as clotting factors. Hemophilia is an inherited (genetic) disorder. There 's no cure yet. But with proper treatment, most people with hemophilia can maintain an active, productive lifestyle. Hemophilia was recognized, though not named, in ancient times. The Talmud, a collection of Jewish Rabbinical writings from the 2nd century AD, stated that male babies did not have to be circumcised if two brothers had already died from the procedure.
The sculpture above is called "The Beauty of Not Knowing" demonstrating the beauty of the doubt. It represents the responsibility and burden that knowledge creates. The distance between each sculpture represents the period of time. The first person in the sculpture is the lightest of all, not because of his body weight, but because of his knowledge. This person thinks he knows everything, as he sees and feels more, but does not observe nor questions all.
Take a moment and imagine a child who has hemophilia and given blood transfusions to save their life now has a disease that will eventually kill them. A young mother with beautiful children, member of the PTA and soccer mom loved by all who is infected by a disease by no fault of her own but by a cheating spouse who passed it on to her. A man who was raped at college now suffers a disease for the rest of his life. What is this disease you may ask that they have been infected with? The disease is Human Immunodeficiency Virus also known as HIV. What is HIV and why is it affecting so many people?