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Zika Virus

Decent Essays

Zika virus (ZIKV), a Flaviviridae family member is an arbovirus transmitted to humans by mosquitoes of the species Aedes aegypti. ZIKV epidemic over the past few years has implicated a rapid incline in neonatal microcephaly and Guillain Barre syndrome has become an immense global health issue. Like other Flavivirus, ZIKV has an enveloped, single positive sense RNA genome. The ZIKV glycosylated non- structural protein-1 (NS1) is known to be the main conserved feature among flavivirus, which interferes with host molecules and is vital in viral replication as well host immune modulation and pathogenesis. However, compared to typical flaviviruses such as dengue virus (DENV) and West Nile virus ,ZIKV NS1 demonstrates independent coding sequence

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