microRNAs Essay

2155 Words9 Pages
Recently we have became aware of the microRNAs (miRNAs) which seem to play a role in oncogenesis. Some of these miRNAs have the potential to become very promising targets for developing cancer therapies. In this study we have taken a look at some of the promising candidates identified in breast cancer; specifically miR-155 and the miR-17-92 cluster. We have examined the potential of these targets to be effected by miRNA silencing techniques. The specific technique we have employed in this study relies on the use of antigomirs, or anti-sense miRNA molecules that were shown to be effective in inhibiting miRNA. We have observed the effects of this prospective therapy in the mouse model of breast cancer. The results indicate that for the…show more content…
Further studies would have to be done to determine if any of these two variable are at fault or if mir-17-92 is even a worthwhile target for antigomir therapy.

Introduction: The fight against cancer is very much perplexing. It could be seen as an ailment that affects the very core of our being. It not some foreign invader but our own body; our own machinery that destroys us. Indeed we have learned much, and todays prognosis is brighter for the patient then it has ever been, but just as we find new therapies we also hit new road blocks. Thus it is imperative to seek out new ways to gain advantage over the disease. miRNA’s seem to offer us a very promising opportunity. These molecules can give us the power to regulate the expression of multiple genes at ones and do so in a fairly un-complicated manner (compared to genetic transformation techniques). miRNA’s have been found in many organisms even including plants. They have been shown to regulate various processes , some as fundamental as development, and differentiation. Their role has been found to be a negative regulator of gene expression. miRNA’s bind to the transcribed mRNA and cause it to be degraded, thus inhibiting the production of the gene product. It is not surprising that in cancer, miRNAs could either inappropriately repress anti-tumor mechanisms (such as steps in the apoptosis pathways) or loss of the miRNA
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