. Provide a paper published in a scientific journal between January 2018 and September 2022 that addresses the role of an example of histone modification in affecting expression of a gene by altering histone acetylation/chromatin state of the DNA encoding that gene.
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1a. Provide a paper published in a scientific journal
between January 2018 and September 2022 that addresses the role of an example of histone
modification in affecting expression of a gene by altering histone acetylation/chromatin state of
the DNA encoding that gene.
Step by step
Solved in 2 steps
- 1a. Provide a paper published in a scientific journal between January 2018 and September 2022 that addresses the role of an example of histone modification in affecting expression of a gene by altering histone acetylation/chromatin state of the DNA encoding that gene. What organism and/or cell type did the authors do their study in?Can you please help with 1a,1b, and 1c please 1a. Find a paper published in a scientific journal between January 2018 and September 2022 that addresses the role of an example of histone modification in affecting expression of a gene by altering histone acetylation/chromatin state of the DNA encoding that gene. What organism and/or cell type did the authors do their study in? 1b. Which histone(s) were affected by the acetylation and/or deacetylation? What gene did they show had altered expression levels in response to the change in histone acetylation? 1c. what effect did the histone modification they studied have on that gene's level of expression - was expression of the gene they examined increased or decreased?1. In a couple of sentences, explain how eukaryotic activator proteins (that are usually gene-specific transcription factors) can enhance transcription even when bound to sequences hundreds or thousands of nucleotide pairs away from a gene’s promoter. 2. Describe three common characteristics of transcription factors. The characteristics may relate to structure, or mechanism of action (PLEASE ANSWER BOTH PLEASE)
- Also, describe what happens when a nonsense mutation is introduced into the gene encoding transposase within a transposon and why is it more likely that insertions or deletions will be more detrimental to a cell than point mutations?1)A. how do you read a sequence of DNA (template or non-template strand) to convert it an mRNA sequence and to a protein? B.How does chromatin remodeling regulate gene transcription? C. What are the major differences between gene expression in bacteria and eukaryotes D. How are non-coding regions involved in gene transcription? E. Explain how eukaryotic genes sometimes produce multiple protein products?5. Please discuss the effect of epigenetic posttranslational modifications on cancer development according to the reading article week 10. Would you think that epigenetic posttranslational modifications could be used as potential therapeutic cancer agents?
- 1. a)how is it possible for such drugs to selectively kill bacterial cells and not our own cells? b)Provide an example of post-translational regulation of protein activity and explain the advantage of regulating each protein/process at the post-translational level instead of the transcriptional level.1. Contrast positive versus negative regulation of gene expression. Describe the role of the repressor in an inducible system and in a repressible system.Discuss Concepts In a mutant strain of E. coli, the CAP protein is unable to combine with its target region of the lac operon. How would you expect the mutation to affect transcription when cells of this strain are subjected to the following conditions? Lactose and glucose are both available. Lactose is available but glucose is not. Both lactose and glucose are unavailable.
- 29. tight packing of previously less condensed chromatin identify which describes the statement above a. pre-transcriptional controlb. transcriptional controlc. translational controld. post-translational controlExplain Phenotypes of mutations in genes encoding transcription factors.5. How the modification and histone interaction with DNA brought to transcriptional silencing. Use Saccharomyces cerevisiae as example to explain the question. Write a short essay. Please answer asap and in short and content should not be palgarised please
