.CHO Cно benzaldehyde cyclohexanecarbaldehyde

Q: Draw a stepwise mechanism for the following Friedel-Crafts acylation. CH3 AICI, + HCI CH

A: Given reaction,

Q: Draw a stepwise, detailed mechanism for the following reaction. CH3NH2 N-CH3 CH,NH, Cr (excess)

A: When nitrogen atom is bonded with three carbon atom is known as tertiary amine.

Q: Q 4: Comparing, Phenol reacts readily than the benzene, so it is a A. nucleophiles B. electrophile…

A: Phenol reacts readily than benzene

Q: Draw a stepwise mechanism for the following reaction, a key step in the synthesis of the…

A: Answer : Step in the synthesis of the anti-inflammatory drug  Celebrex is :

Q: Draw a stepwise mechanism for the following reaction.

A: Since on reaction with the H2SO4 , the OH group will take a proton from the H2SO4 and leave as water…

Q: HNO3 H₂SO4 er nitration reaction, the nitro substituent in the product will be located on carbon…

A: In nitration reaction, the -NO2 substituent is attached to a carbon atom depending upon the ortho,…

Q: HBr "SN1-like" H :0. :Br: H 2° alcohol 3° alkyl bromide

A: Given reaction follows Sn1 mechanism.

Q: Which will form a more stable enol? Why? VS

A:

Q: Rank the following according to increasing reactivity with 1 as the least reactive, and 4 as the…

A: The reactivity order for nucleophilic acyl substitution is as follows:

Q: Ethers are oxidized with O2 to form hydroperoxides that decompose violently when heated. Draw a…

A:

Q: Draw a stepwise mechanism for the following substitution. Explain why 2-chloropyridine reacts faster…

A: Given reaction,

Q: Draw a stepwise mechanism for the following Robinson annulation. This reaction was a key step in a…

A:

Q: Vhich is the better nucleophile in protic solvent? or O CI-

A: Solvent which gives hydrogen ions in solution called as polar protic solvent whereas solvent which…

Q: he cyano group is often considered to be more stable than esters or even amides vhen reacting with a…

A: Introduction :  We have to tell why cyanide is a stable nucleophile.

Q: Draw a stepwise mechanism for the following reaction. (Hint: Conjugate addition can occur with…

A: Given reaction is,

Q: Why alkyl halides are considered to be very reactive compounds towards nucleophile? they have a…

A: Introduction: We have to explain which is correct statement for the above question.

Q: Draw a stepwise, detailed mechanism for the following reaction.

A: The given reaction is,

Q: Draw a stepwise, detailed mechanism for the following reaction. но + H20 H2SO4

A: In organic reaction, ring expansion takes place to form 6 membered rings.

Q: -Cf3 Nucleophilic Attack

A:

Q: Draw a stepwise, detailed mechanism for the dienone–phenol rearrangement, a reaction that forms…

A: Please find below the reaction mechanism.

Q: Draw a stepwise mechanism for the following reaction.

A:

Q: Acidity of carboxylic acids can be increased by EWGS because Select one: O a. Stabilization of…

A:

Q: Is a intramolecular Friedel Crafts acylation reaction. As you from the product, the acylation…

A: Applying concept of organic synthesis and reagent.

Q: Draw the major E2 elimination products from each of the attached alkyl halides.

A: E2 elimination stаnds fоr bimоleсulаr eliminаtiоn. The reасtiоn invоlves а оne-steр meсhаnism in…

Q: Draw a stepwise, detailed mechanism for the following intramolecular reaction.

A: SOLUTION: Step 1: The intramolecular ring closure is carried out in the presence of strong acid like…

Q: Explain why quinuclidine is a much more reactive nucleophile than triethylamine, even though both…

A:

Q: Explain why quinuclidine is a much more reactive nucleophile thantriethylamine, even though both…

A: The chemical species that donates a pair of electron to form a chemical bond is called a…

Q: Draw a stepwise mechanism for the following substitution. Explain why 2-chloropyridine reacts faster…

A: Methoxide ion reacts with imine carbon of 2-chloropyridine to form amide ion.

Q: Label the α and β carbons in attached alkyl halide. Draw all possible elimination products formed…

A: Biomolecular elimination (E2) reaction: E2 reaction involves a one-step mechanism in which…

Q: Draw a stepwise mechanism for the following reaction.

A: The given reaction is haloydrin formation reaction where a halogenated enol intermediate is formed…

Q: Draw a stepwise mechanism for the following reaction that forms ether D. D can be converted to the…

A: Since KOC(CH3)3 is a strong base. Hence it will take proton from the OH group and convert it into O-…

Q: 1. reactivity towards nucleophilic acyl substitution CI HO, RANKING:

A: Nucleophile are those species which attacks on electron deficient species. In carboxylic acid and…

Q: Draw a stepwise, detailed mechanism for the following reaction.

A:

Q: Draw enol tautomer(s) for each attached compound. Ignore stereoisomers.

A: Introduction: Those compounds which the same molecular formula but differ in the position of protons…

Q: Rank the following compounds in order of increasing reactivity in nucleophilic addition.

A: Given compounds,

Q: How do I do this?

A:

Q: Which carbonyl group in each pair absorbs at a higher frequency?

A:

Q: Draw a stepwise mechanism for the following reaction, a key step in thesynthesis of the…

A:

Q: Draw the products formed when attached compound is treated with HNO3 and H2SO4. State whether the…

A:

Q: Arrange in decreasing order according to their reactivity towards an electrophile. H A В

A:

Q: Explain why benzaldehyde is less reactive than cyclohexanecarbaldehyde toward nucleophilic attack.

A: The reactivity of aldehyde is dependent upon the electrophilic character of carbonyl carbon. If…

Q: CI CI HCI (xs)

A:

Q: Explain why the trifluoromethane sulfonate (TfO-) ion is a better leaving group than the…

A: An electron withdrawing group withdraws the electron density from a reaction center. Examples of…

Q: Rank the following compounds from most reactive to least reactive toward nucleophilic addition:

A: Reactivity towards nucleophilic addition reaction depends upon how much electrophilic nature of…

Q: (c) With increasing nucleophilicity (1: least nucleophilic; 3: most nucleophilic) ОН CHO.

A: Given nucleophilicity order

Q: An alternative solvent to alkylate saccharin nucleophile could have been another OA. protic; ethanol…

A: Given statement is :  An alternative solvent to alkylated saccharin nucleophile could have been…

Q: Draw a stepwise, detailed mechanism for the following intramolecular reaction that forms a cyclic…

A: The given reaction is  To find: The stepwise mechanism for the given intramolecular reaction

Q: Determine whether each nucleophilic acyl substitution is likely to occur.

A: Nucleophilic Substitution reaction:  When a nucleophile attacks an electron deficient center also…

Q: 4-Methylpyridine reacts with benzaldehyde (C6H5CHO) in the presence of base to form A. (a) Draw a…

A: a) A stepwise mechanism of the given reaction is,

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.