.S.CHзcO2но Со2ноcozintermediate thioester1-isopropylmalateBiosynthesis of leucine involves conversion of an intermediate thioester to 1-isopropyl malate (see above). This proceeds in in twosteps followed by a proton transfer. Write a detailed mechanism for this conversion. Then, draw the intermediate (or compound)produced in step 1.• You do not have to consider stereochemistry.• Draw uninvolved carboxyl groups in the anionic state, and enolates as carbanions.• When needed, abbreviate CoenzymeA-S- as CH,S- in your drawing.

The conversion of the given reactant thioester into 1-isopropylmalate occurs in two steps. First…

Answered: .S. CHз cO2 но Со2 но coz intermediate…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 42MP

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