1. На0, кон 2. Н,О, НС он HO, HO. p-cresol chloroacetic acid p-methylphenoxyacetic acid

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter13: Substitution
Section: Chapter Questions
Problem 37CTQ
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Draw the reaction mechanism for the Williamson Ether reaction. Cresol is the nucleophilic component of the ether synthesis reaction and chloroacetic acid is the electrophilic component. Due to cresol being weak, a strong nucleophile has to be made before the reaction can begin. A base of KOH is added with cresol so that nucleophile can be strong before it is mixed with chloroacetic acid. 

он
кон
phenol
(weak nucleophile)
phenoxide
(stronger nucleophile)
Transcribed Image Text:он кон phenol (weak nucleophile) phenoxide (stronger nucleophile)
1. НаО, КоН
2. Н-О, HС
он
HO.
p-cresol
chloroacetic acid
p-methylphenoxyacetic acid
Transcribed Image Text:1. НаО, КоН 2. Н-О, HС он HO. p-cresol chloroacetic acid p-methylphenoxyacetic acid
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