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1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. -B Brec (Inactive) Plasma Membrane Stimulate C-P D (Inactive) C-O growth of blood vessels into tumors O-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).

1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. -B Brec (Inactive) Plasma Membrane Stimulate C-P D (Inactive) C-O growth of blood vessels into tumors O-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).

Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter16: Regulation Of Gene Expression
Section: Chapter Questions
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Describe the steps of the signal transduction pathway for the cancer cells of today's Learn About It and Try It.

Directions: 1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. 2... B Brec (Inactive) Plasma Membrane Stimulate growth of blood vessels into tumors C-P D (Inactive) C-O P-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).
Transcribed Image Text:Directions: 1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. 2... B Brec (Inactive) Plasma Membrane Stimulate growth of blood vessels into tumors C-P D (Inactive) C-O P-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).
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