Question
Asked Dec 7, 2019
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1. There are two metabolic routes for the conversion of oxaloacetate to
phosphoenolpyruvate (PEP). What factors
likely indicate which route is used? Do the
two routes have different requirements for cellular energy (e.g. ATP)?
2. Compare the export of glucose from hepatocytes to the import into hepatocytes.
3. Would you expect anaplerotic reactions to be active
in the postprandial hepatocyte?
Why?
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  • The conversion of oxaloacetate into phosphoenolpyruvate (PEP) is carried out by the enzyme PEP carboxykinase. This enzyme plays an important role in the gluconeogenesis cycle for the production of glucose from citric acid cycle intermediate oxaloacetate. It requires a molecule of GTP (guanosine triphosphate) and one molecule of carbon dioxide is released.
  • Another route for conversion of oxaloacetate to PEP is the fermentative route for succinate prod...

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