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32CHAPTER 3 Quantifying the Extent ofTABLETABLE 3-10 Alcohol Use and Outcome of PregnancyDelivered FullTermMiscarriage4Chole14Heavy alcohol usemeNo heavy alcohol4636PlacuseఈTABLE 3-11 Incident Coronary Artery Diseaseby TreatmentNumber withNumber ofCoronary ArteryParticipantsDiseaseCholesterolmedication40028Placebo4404004270the first trimester of pregnancy and miscarriage. Fiftywomen who suffered miscarriage are enrolled, alongwith 50 who delivered full-term. Each participant'suse of alcohol during pregnancy is ascertained.Heavy drinking is defined as four or more drinks onone occasion. The data are shown in Table 3-10.a. Compute the odds of miscarriage in women withheavy alcohol use during pregnancyb. Compute the odds of miscarriage in women withno heavy alcohol use during pregnancy. TABLE 3-12 Total Follow-Up Time by TreatmentNumber withTotal Follow-Up(years)CoronaryArtery DiseaseCholesterol345128medication298442Placeboc. Which measure is more appropriate in thisdesign, the relative risk or odds ratio? Justifybriefly.5In the study described in Problem 4, some patientswere not followed for a total of 10 years. Some sufferedrants (i e develonedco

Question

a. Compute the relative risk of coronary artery disease in patients receiving the new cholesterol medication as compared to those receiving a placebo.

b. Compute the odds ratio of coronary artery disease in patients receiving the new cholesterol medication as compared to those receiving a placebo.

c. Which measure is more appropriate in this design, the relative risk or odds ratio? Justify briefly. 

32
CHAPTER 3 Quantifying the Extent of
TABLE
TABLE 3-10 Alcohol Use and Outcome of Pregnancy
Delivered Full
Term
Miscarriage
4
Chole
14
Heavy alcohol use
me
No heavy alcohol
46
36
Plac
use
ఈ
TABLE 3-11 Incident Coronary Artery Disease
by Treatment
Number with
Number of
Coronary Artery
Participants
Disease
Cholesterol
medication
400
28
Placebo
440
400
42
70
the first trimester of pregnancy and miscarriage. Fifty
women who suffered miscarriage are enrolled, along
with 50 who delivered full-term. Each participant's
use of alcohol during pregnancy is ascertained.
Heavy drinking is defined as four or more drinks on
one occasion. The data are shown in Table 3-10.
a. Compute the odds of miscarriage in women with
heavy alcohol use during pregnancy
b. Compute the odds of miscarriage in women with
no heavy alcohol use during pregnancy.
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32 CHAPTER 3 Quantifying the Extent of TABLE TABLE 3-10 Alcohol Use and Outcome of Pregnancy Delivered Full Term Miscarriage 4 Chole 14 Heavy alcohol use me No heavy alcohol 46 36 Plac use ఈ TABLE 3-11 Incident Coronary Artery Disease by Treatment Number with Number of Coronary Artery Participants Disease Cholesterol medication 400 28 Placebo 440 400 42 70 the first trimester of pregnancy and miscarriage. Fifty women who suffered miscarriage are enrolled, along with 50 who delivered full-term. Each participant's use of alcohol during pregnancy is ascertained. Heavy drinking is defined as four or more drinks on one occasion. The data are shown in Table 3-10. a. Compute the odds of miscarriage in women with heavy alcohol use during pregnancy b. Compute the odds of miscarriage in women with no heavy alcohol use during pregnancy.

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TABLE 3-12 Total Follow-Up Time by Treatment
Number with
Total Follow-Up
(years)
Coronary
Artery Disease
Cholesterol
3451
28
medication
2984
42
Placebo
c. Which measure is more appropriate in this
design, the relative risk or odds ratio? Justify
briefly.
5
In the study described in Problem 4, some patients
were not followed for a total of 10 years. Some suffered
rants (i e develoned
co
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TABLE 3-12 Total Follow-Up Time by Treatment Number with Total Follow-Up (years) Coronary Artery Disease Cholesterol 3451 28 medication 2984 42 Placebo c. Which measure is more appropriate in this design, the relative risk or odds ratio? Justify briefly. 5 In the study described in Problem 4, some patients were not followed for a total of 10 years. Some suffered rants (i e develoned co

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check_circleAnswer
Step 1

Amongst the provided tables, table 3-11 is used to answer the asked questions.

a) The relative risk of coronary artery disease in patients receiving the new cholesterol medication as compared to those receiving a placebo can be obtained as:

Relative RiskPoint PrevalenceExposed
Point PrevalenceUnesposed
28
400
42
400
0.07
0.105
0.67
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Relative RiskPoint PrevalenceExposed Point PrevalenceUnesposed 28 400 42 400 0.07 0.105 0.67

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Step 2

b) The odd ratio of coronary artery disease in patients receiving the new choleste...

Point PrevalenceExposed
1-Point Prevalencesed
Point PrevalenceUmposed
1 Point Prevalence posd
Odd Ratio
28
400
28
1
400
42
400
42
1 -
400
0.07
0.93
0.105
0.895
0.0752
0.1173
-0.64
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Point PrevalenceExposed 1-Point Prevalencesed Point PrevalenceUmposed 1 Point Prevalence posd Odd Ratio 28 400 28 1 400 42 400 42 1 - 400 0.07 0.93 0.105 0.895 0.0752 0.1173 -0.64

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