5. The nucleotide sequences of the DNA molecules in the figure below were obtained from four different individuals, one wild type and three mutants. Wild Type 5'-TTATCCATGATCGGATCGATCCATTAGCCGA-3' 3'-AATAGGTACTAGCCTAGCTAGGTAATCGGCT-5’ Mutant I 5'-ATCCATGATCGGATTGATCCATTAGCCGAAT-3’ 3'-TAGGTACTAGCCTAACTAGGTAATCGGCTTA-5’ Mutant II 5'-CCGTTATCCATGATCGGATAGATCCATTAGCC-3’ 3'-GGCAATAGGTACTAGCCTATCTAGGTAATCGG-5’ Mutant III 5'-CACCGTTATCCATGATCGGAACGATCCATTAGC-3’ 3'-CAGGCAATAGGTACTAGCCTTGCTAGGTAATCG-5’ a) Identify the open reading frames in each sequence of DNA and translate them into proteins. Write down the sequence of amino acids that will be obtained after translation: b) Which of the mutations above would be least likely to cause a change in the function of the protein? Why? c) Which of the mutations above would probably cause a major disruption in the function of the protein? Why?

Question
5. The nucleotide sequences of the DNA molecules in the figure below were obtained
from four different individuals, one wild type and three mutants.
Wild Type
5'-TTATCCATGATCGGATCGATCCATTAGCCGA-3'
3'-AATAGGTACTAGCCTAGCTAGGTAATCGGCT-5’
Mutant I
5'-ATCCATGATCGGATTGATCCATTAGCCGAAT-3’
3'-TAGGTACTAGCCTAACTAGGTAATCGGCTTA-5’
Mutant II
5'-CCGTTATCCATGATCGGATAGATCCATTAGCC-3’
3'-GGCAATAGGTACTAGCCTATCTAGGTAATCGG-5’
Mutant III
5'-CACCGTTATCCATGATCGGAACGATCCATTAGC-3’
3'-CAGGCAATAGGTACTAGCCTTGCTAGGTAATCG-5’
a) Identify the open reading frames in each sequence of DNA and translate them
into proteins. Write down the sequence of amino acids that will be obtained after
translation:
b) Which of the mutations above would be least likely to cause a change in the
function of the protein? Why?
c) Which of the mutations above would probably cause a major disruption in the
function of the protein? Why?
Expand
Transcribed Image Text

5. The nucleotide sequences of the DNA molecules in the figure below were obtained from four different individuals, one wild type and three mutants. Wild Type 5'-TTATCCATGATCGGATCGATCCATTAGCCGA-3' 3'-AATAGGTACTAGCCTAGCTAGGTAATCGGCT-5’ Mutant I 5'-ATCCATGATCGGATTGATCCATTAGCCGAAT-3’ 3'-TAGGTACTAGCCTAACTAGGTAATCGGCTTA-5’ Mutant II 5'-CCGTTATCCATGATCGGATAGATCCATTAGCC-3’ 3'-GGCAATAGGTACTAGCCTATCTAGGTAATCGG-5’ Mutant III 5'-CACCGTTATCCATGATCGGAACGATCCATTAGC-3’ 3'-CAGGCAATAGGTACTAGCCTTGCTAGGTAATCG-5’ a) Identify the open reading frames in each sequence of DNA and translate them into proteins. Write down the sequence of amino acids that will be obtained after translation: b) Which of the mutations above would be least likely to cause a change in the function of the protein? Why? c) Which of the mutations above would probably cause a major disruption in the function of the protein? Why?

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