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== A Toxoplasma gondii mutant (shown below) was made by Hunter and Sibley. The mutant T. gondii had a truncated ROP18 gene which prevented ROP 18 from binding to the parasitophorous vacuole as shown in the figure below. What would you expect to see when a host mouse was infected with this mutant T. gondii? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b с Question 3 Homework Unanswered d e b Full-length ROP18 Prodomain Signal peptide Low-complexity basic regions Membrane targeting Catalytic domain ROP18 881 Nucleus Ser/The kinase T.gondi Truncated ROPIS ROPIS P The mutated ROP18 protein would bind with IRG proteins in the cytoplasm and neutralize the effects of IRG. Nature Reviews | Microbiology The mouse would have difficulty clearing the T. gondii infection due to the mutated ROP18 since the mutation would decrease the host's defenses against the parasite. The ROP18 mutation would have no effect on the host's ability to clear the T. gondii infection since ROP18 is not involved in parasitic defense. The mouse would clear the T. gondii infection more effectively since the parasitic defense protein is mutated and has an altered function. The mouse would clear the T. gondii infection more effectively since the ROP18 mutation increased the function of the host defense proteins.

== A Toxoplasma gondii mutant (shown below) was made by Hunter and Sibley. The mutant T. gondii had a truncated ROP18 gene which prevented ROP 18 from binding to the parasitophorous vacuole as shown in the figure below. What would you expect to see when a host mouse was infected with this mutant T. gondii? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b с Question 3 Homework Unanswered d e b Full-length ROP18 Prodomain Signal peptide Low-complexity basic regions Membrane targeting Catalytic domain ROP18 881 Nucleus Ser/The kinase T.gondi Truncated ROPIS ROPIS P The mutated ROP18 protein would bind with IRG proteins in the cytoplasm and neutralize the effects of IRG. Nature Reviews | Microbiology The mouse would have difficulty clearing the T. gondii infection due to the mutated ROP18 since the mutation would decrease the host's defenses against the parasite. The ROP18 mutation would have no effect on the host's ability to clear the T. gondii infection since ROP18 is not involved in parasitic defense. The mouse would clear the T. gondii infection more effectively since the parasitic defense protein is mutated and has an altered function. The mouse would clear the T. gondii infection more effectively since the ROP18 mutation increased the function of the host defense proteins.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A Toxoplasma gondii mutant (shown below) was made by Hunter and Sibley. The mutant T. gondii had a truncated ROP18 gene which prevented ROP 18 from binding to the parasitophorous vacuole as shown in the figure below. What would you expect to see when a host mouse was infected with this mutant T. gondii? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b с Question 3 Homework. Unanswered d e b Full-length ROP18 Prodomain, Signal peptide N- Low-complexity basic regions 10 Membrane targeting Catalytic domain ROP18 888 Nucleus Ser/Thr kinase 87118 900 69 000 Ø 8888 T. gondii C C Truncated ROP18 The mutated ROP18 protein would bind with IRG proteins in the cytoplasm and neutralize the effects of IRG. N ROP18 8 8 The mouse would have difficulty clearing the T. gondii infection due to the mutated ROP18 since the mutation would decrease the host's defenses against the parasite. 88 The ROP18 mutation would have no effect on the host's ability to clear the T. gondii infection since ROP18 is not involved in parasitic defense. Nature Reviews | Microbiology The mouse would clear the T. gondii infection more effectively since the parasitic defense protein is mutated and has an altered function. ★ The mouse would clear the T. gondii infection more effectively since the ROP18 mutation increased the function of the host defense proteins. d -C ОР
Transcribed Image Text:A Toxoplasma gondii mutant (shown below) was made by Hunter and Sibley. The mutant T. gondii had a truncated ROP18 gene which prevented ROP 18 from binding to the parasitophorous vacuole as shown in the figure below. What would you expect to see when a host mouse was infected with this mutant T. gondii? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b с Question 3 Homework. Unanswered d e b Full-length ROP18 Prodomain, Signal peptide N- Low-complexity basic regions 10 Membrane targeting Catalytic domain ROP18 888 Nucleus Ser/Thr kinase 87118 900 69 000 Ø 8888 T. gondii C C Truncated ROP18 The mutated ROP18 protein would bind with IRG proteins in the cytoplasm and neutralize the effects of IRG. N ROP18 8 8 The mouse would have difficulty clearing the T. gondii infection due to the mutated ROP18 since the mutation would decrease the host's defenses against the parasite. 88 The ROP18 mutation would have no effect on the host's ability to clear the T. gondii infection since ROP18 is not involved in parasitic defense. Nature Reviews | Microbiology The mouse would clear the T. gondii infection more effectively since the parasitic defense protein is mutated and has an altered function. ★ The mouse would clear the T. gondii infection more effectively since the ROP18 mutation increased the function of the host defense proteins. d -C ОР
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