Acid-catalyzed transesterification and Fischer esterification take place by nearly identical mechanisms. Transesterificationcan also take place by a base-catalyzed mechanism, but all attempts at base-catalyzed Fischer esterification (using -OR″,for example) seem doomed to failure. Explain why Fischer esterification cannot be catalyzed by base.2

Acid-catalyzed transesterification and Fischer esterification take place by nearly identical mechanisms. Transesterificationcan also take place by a base-catalyzed mechanism, but all attempts at base-catalyzed Fischer esterification (using -OR″,for example) seem doomed to failure. Explain why Fischer esterification cannot be catalyzed by base.2

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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