Adult hemoglobin is a multimeric protein with fourpolypeptides, two of which are α-globin and two ofwhich are β-globin.a. How many genes are needed to define the structureof the hemoglobin protein?b. If a person is heterozygous for wild-type allelesand alleles that would yield amino acid substitutionvariants for both α-globin and β-globin, how manydifferent kinds of hemoglobin protein would befound in the person’s red blood cells and in whatproportion? Assume all alleles are expressed at thesame level.
Adult hemoglobin is a multimeric protein with fourpolypeptides, two of which are α-globin and two ofwhich are β-globin.a. How many genes are needed to define the structureof the hemoglobin protein?b. If a person is heterozygous for wild-type allelesand alleles that would yield amino acid substitutionvariants for both α-globin and β-globin, how manydifferent kinds of hemoglobin protein would befound in the person’s red blood cells and in whatproportion? Assume all alleles are expressed at thesame level.
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter15: Genomes And Genomics
Section: Chapter Questions
Problem 1QP: The gene controlling ABO blood type and the gene underlying nail-patella syndrome are said to show...
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Adult hemoglobin is a multimeric protein with four
polypeptides, two of which are α-globin and two of
which are β-globin.
a. How many genes are needed to define the structure
of the hemoglobin protein?
b. If a person is heterozygous for wild-type alleles
and alleles that would yield amino acid substitution
variants for both α-globin and β-globin, how many
different kinds of hemoglobin protein would be
found in the person’s red blood cells and in what
proportion? Assume all alleles are expressed at the
same level.
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