Among the most prevalent pathologies that afflicthuman beings is heart disease, which can have a severeimpact on quality of life and can even result in prematuredeath. While heart disease mostly afflicts those who areolder, 1% or 2% of people in their 30s, and even in their20s, suffer from this disease. Genetic and environmentalcomponents of this disease exist. What strategy mightyou use to choose families to participate in a GWAS ofheart disease–causing genes? Explain your reasoning.

Question

Among the most prevalent pathologies that afflict
human beings is heart disease, which can have a severe
impact on quality of life and can even result in premature
death. While heart disease mostly afflicts those who are
older, 1% or 2% of people in their 30s, and even in their
20s, suffer from this disease. Genetic and environmental
components of this disease exist. What strategy might
you use to choose families to participate in a GWAS of
heart disease–causing genes? Explain your reasoning.

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