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Bacillus Anthracis virulence factors, pathogenesis, transmission and epidemiology,  treatment

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Bacillus Anthracis virulence factors, pathogenesis, transmission and epidemiology,  treatment

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Step 1

Bacillus anthracis is an endospore-forming gram-positive bacterium. It is a rod-shaped bacterium with 1.0-1.2 micrometer width and 3-5 micrometer length. This bacterium is responsible for the infection, anthrax. Anthrax is a very common livestock disease, which is generally seen in humans. It can easily grow in normal nutrient medium and in aerobic or anaerobic conditions.

Step 2

Bacillus anthracis contains three types of primary virulence factors, an extracellular poly-D-glutamate capsule (D-PGA capsule), edema toxin (ET), and lethal toxin (LT). these factors are induced by the presence of carbon dioxide, physiological temperature, and the presence of bicarbonate in mammalian hosts. D-PGA capsule is formed by the enzymes, CapA, CapB, and CapC, which are encoded by the gene capBCAD. ET and LT toxins are composed of enzymatic A-components edema factor (EF) or lethal factor (LF), respectively.

Step 3

The pathogenic process of Bacillus anthracis is done by using capsule and toxins, which contains different kind of proteins. The combination of edema toxin and lethal toxin can result in induction of severe cases of the diseases. The edema toxin contains an edema factor and the protective antigen, and...

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