Br NH2 OH CI A B C E

Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter31: Immunochemistry
Section: Chapter Questions
Problem 31.75P
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Question

Rank the attached compounds in order of increasing reactivity in a
substitution reaction with CN as nucleophile.

Br
NH2
OH
CI
A
B
C
E
Transcribed Image Text:Br NH2 OH CI A B C E
Expert Solution
Step 1

Nucleophilicity is defined as the tendency to give the electrons.

And, a better nucleophile can easily lose its pair of electrons.

In an aromatic substitution reaction, a better leaving group leads the faster reactivity. 

 

 

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