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- For most cases, a p value of 0.05 is used to determine whether results fit expected values. Is this a magic number, or could p values be set more stringently, say 0.01, or more lax, say 0.10? What effect would these values have on the reliability of the chi-square test?Is there any difference between the alignments, alignment scores, identity percentages, positives and gaps? If so, what is your explanation for the differences?Which of the following pairs of sequences would be considered different alleles in DNA profiling? a) ATGAATTCGG; ATGAAATCGG b) ATGAATTCGG; TACTTACTTACT c) GAAGAAGAA; GAAGAAGAAGAA d) AATAATAATAAT; AATTAATTAATT
- If only the first five loci listed in Table 1 of the assigned paper (Forensics, DNA Fingerprinting, and CODIS) were analyzed, what would be the statistical probability of finding that particular genotype among people other than Suspect B? SHOW YOUR WORK! Hint: Multiply together the frequencies of the individual STR genotypes to obtain the overall profile frequency.a. It is possible to perform DNA fingerprinting withSNPs instead of SSRs as DNA markers, but ingeneral you would need to examine more SNPmarkers than the 13 SSRs used in the CODIS database to be sure of a match. Explain why.b. DNA fingerprinting has been used to verify pedigrees of valuable animals such as show dogs, racinggreyhounds, and thoroughbred horses. However, thetechnology is much harder to apply in these casesthan it is in forensic applications for humans. In particular, many more DNA markers must be examinedin domesticated animals to establish the identity orclose familial relationship of two DNA samples.Why would you need to look at more polymorphicloci in these animals than you would in humans?Comparing SNPs to STR markers, which of the following are true? Select one: a. SNP loci generally have more alleles than STR loci. b. SNP loci could not be used for forensic CODIS DNA profiling. c. SNPs are not the same as microsatellite DNA. d. There are many more STR loci in the human genome than SNP markers.
- What is the molecular level of shingles? Break it down when explaining at least a paragraph. cite credible sources, pleaseExplain the similarities and differences between the procedures used for the coarse-scale mapping and finescale mapping of QTLs through controlled crosses, as was accomplished for QTLs involved with tomato size.On the assumption that the two profiles arise from twogenetically related individuals, law enforcement agenciespursue relatives of the person whose profile is stored in theDNA database. Testing in these cases is known as familialDNA testing. Should such searches be considered scientificallyvalid or even ethical?
- Explain the multiple testing problem of GWAS - why do we need such a small p-value to achieve significance?What are the two missing genotypes in the Table above ? What is the map distances between the bd and ps loci ? Assuming the map distances are additive, what is the interference ? this is a practice question please helpExplain this statement "Major considerations in dosage form design with example" ? Please briefly explain at your own easy words.